Title:
OPHTHALMIC DRUG DELIVERY SYSTEM USING POLYMER MICELL
Document Type and Number:
WIPO Patent Application WO/2004/087103
Kind Code:
A1
Abstract:
The current situation is such that it is difficult for drugs to reach posterior tissues of eyeball, such as choroid and retina, with the result that treating diseases in such regions is difficult. Thus, how to attain effective delivery of drugs is of importance. It has been found that effective delivery of drugs to posterior tissues of eyeball, such as choroid and retina, especially those wherein vascularization has occurred can be accomplished by systemic administration, especially intravenous administration of polymer micells having a drug incorporated therein. Further, it has been found that when a photosensitive substance is used as a drug and PDT is carried out, choroidal neo-vessels can be effectively choked so as to be useful for the treatment of age-related macular degeneration.
Inventors:
KATAOKA KAZUNORI (JP)
TAMAKI YASUHIRO (JP)
HARADA ATSUSHI (JP)
TASAKA FUMITAKA (JP)
TAMAKI YASUHIRO (JP)
HARADA ATSUSHI (JP)
TASAKA FUMITAKA (JP)
Application Number:
PCT/JP2004/004412
Publication Date:
October 14, 2004
Filing Date:
March 29, 2004
Export Citation:
Assignee:
NANOCARRIER KABUSHIKI KAISHA (JP)
KATAOKA KAZUNORI (JP)
TAMAKI YASUHIRO (JP)
HARADA ATSUSHI (JP)
TASAKA FUMITAKA (JP)
KATAOKA KAZUNORI (JP)
TAMAKI YASUHIRO (JP)
HARADA ATSUSHI (JP)
TASAKA FUMITAKA (JP)
International Classes:
A61K9/00; A61K9/107; A61K31/409; A61K41/00; A61K47/30; A61K47/34; A61K47/42; A61K47/48; A61P27/02; (IPC1-7): A61K9/107; A61K31/409; A61K47/34; A61K47/42; A61P27/02
Foreign References:
| JP2001206885A | 2001-07-31 |
Other References:
SCHMIDT-ERFURTH U. ET AL.: "Photodynamic therapy with verteporfin for choroidal neovascularization caused by age-related macular degeneration", ARCH. OPHTALMOL., vol. 117, 1999, pages 1177 - 1187, XP000853995
WU R.P. ET AL.: "Incorporation efficiency of porphyrins in micelles", ABSTRACTS PAP. 224TH ACS NATIONAL MEET. (ART.181), 2002, XP002904093
YOKOYAMA MASAYUKI: "Biryushi carriel ni yoru passive targetting", DRUG DELIVERY SYSTEM, vol. 14, no. 6, 1999, pages 449 - 457, XP002904094
STAPERT H.R. ET AL.: "Polyion complex micelles encupsulating light-harvesting ionic dendrimer zinc porphyrins", LANGMUIR, vol. 16, 2000, pages 8182 - 8188, XP002941415
WU R.P. ET AL.: "Incorporation efficiency of porphyrins in micelles", ABSTRACTS PAP. 224TH ACS NATIONAL MEET. (ART.181), 2002, XP002904093
YOKOYAMA MASAYUKI: "Biryushi carriel ni yoru passive targetting", DRUG DELIVERY SYSTEM, vol. 14, no. 6, 1999, pages 449 - 457, XP002904094
STAPERT H.R. ET AL.: "Polyion complex micelles encupsulating light-harvesting ionic dendrimer zinc porphyrins", LANGMUIR, vol. 16, 2000, pages 8182 - 8188, XP002941415
Attorney, Agent or Firm:
Hibi, Norihiko c/o KISHIMOTO & CO. 3rd Floor (Inaba Building 13-18, Nishishinsaibashi
1-chome, Chuo-ku, Osaka-sh, Osaka 86, JP)
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