Title:
OPHTHALMIC LIQUID PREPARATION
Document Type and Number:
WIPO Patent Application WO/2022/097731
Kind Code:
A1
Abstract:
The objective of the present invention is to reduce the cellular cytotoxicity of an algefacient and/or strengthen the cooling sensation of the algefacient. It was discovered that the cellular toxicity of menthol, which is the algefacient, was reduced and the cooling sensation of menthol was strengthened by blending brimonidine into an ophthalmic preparation containing menthol, which is the algefacient. Furthermore, an ophthalmic composition into which brimonidine and an algefacient selected from the group consisting of bergamot oil, geraniol, and borneol have been blended similarly exhibited a reduction in the cellular cytotoxicity, induced by the algefacient, as a result of blending in the brimonidine. On the basis of the above results, the present invention provides a ophthalmic preparation containing an algefacient and brimonidine.
Inventors:
NAKASE SHUNSUKE (JP)
BANDO TAKASHI (JP)
BANDO TAKASHI (JP)
Application Number:
PCT/JP2021/040868
Publication Date:
May 12, 2022
Filing Date:
November 05, 2021
Export Citation:
Assignee:
EYE THERAPIES LLC (US)
International Classes:
A61K9/08; A61K31/498; A61K47/10; A61P27/02; A61P43/00
Foreign References:
| JP2011529894A | 2011-12-15 | |||
| JP2016185940A | 2016-10-27 | |||
| JP2020033290A | 2020-03-05 | |||
| JP2020523312A | 2020-08-06 |
Attorney, Agent or Firm:
AOKI, Atsushi et al. (JP)
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