OPHTHALMIC PREPARATION OF TYROSINE KINASE INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF

WIPO Patent Application WO/2023/103835

A1

An ophthalmic preparation of a tyrosine kinase inhibitor suitable for eye drop administration is prepared from the following raw materials and adjuvants in parts by weight: active ingredient: 0.5-1.5 parts of a tyrosine kinase inhibitor, wherein the content of the active ingredient in the ophthalmic preparation is 0.1-1 mg/mL; and pharmaceutically acceptable adjuvants: 20-300 parts of a surfactant, 0.5-70 parts of a tackifier, 10-800 parts of a solubilizer, and the balance of a solvent. The ophthalmic preparation can effectively deliver the active ingredient to the fundus oculi to treat fundus angiogenesis diseases, has a high absorption and utilization rate, a small particle size and a good stability, and is suitable for preparing a sterile preparation by means of a microporous filter membrane sterilization method and/or a high-temperature sterilization method.

DONG QING (CN)
ZHANG SHU (CN)
XUE LUBING (CN)
TANG XIN (CN)

PCT/CN2022/134961

June 15, 2023

November 29, 2022

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CHENGDU RUIMU BIOMEDICAL TECH CO LTD (CN)

A61K9/10; A61K31/404; A61K31/44; A61K45/00; A61K47/34; A61K47/36; A61K47/38; A61K47/44; A61P9/10; A61P27/02; A61P27/06

WO2006117666A2

2006-11-09

US20150196649A1	2015-07-16
CN103110597A	2013-05-22
CN102340993A	2012-02-01
CN110664757A	2020-01-10
CN107708664A	2018-02-16
US20190015409A1	2019-01-17
CN112770724A	2021-05-07

GAOYUNG INTELLECTUAL PROPERTY AGENCY (GENERAL PARTNERSHIP) (CN)

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