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Title:
OPTICALLY ACTIVE 1-ARYL-2-FLUORO-SUBSTITUTED ETHYLAMINE AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2005/085174
Kind Code:
A1
Abstract:
Disclosed is a method for producing an optically active 1-aryl-2-fluoro-substituted ethylamine represented by the following general formula [2]: [wherein Ar represents an aryl group; n represents an integer of 1 or 2; and * represents an asymmetric carbon] or a salt thereof by hydrogenolyzing an optically active secondary amine represented by the following general formula [1]: [wherein Ar represents an aryl group; n represents an integer of 1 or 2; and * represents an asymmetric carbon] or a salt thereof in the presence of a group VIII transition metal catalyst.

Inventors:
ISHII AKIHIRO
KANAI MASATOMI
KURIYAMA YOKUSU
YASUMOTO MANABU
INOMIYA KENJIN
OOTSUKA TAKASHI
SUTO KATSUHIDE
UEDA KOJI
Application Number:
PCT/JP2005/002740
Publication Date:
September 15, 2005
Filing Date:
February 21, 2005
Export Citation:
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Assignee:
CENTRAL GLASS CO LTD (JP)
ISHII AKIHIRO
KANAI MASATOMI
KURIYAMA YOKUSU
YASUMOTO MANABU
INOMIYA KENJIN
OOTSUKA TAKASHI
SUTO KATSUHIDE
UEDA KOJI
International Classes:
C07C209/26; C07B61/00; C07C209/52; C07C209/60; C07C209/62; C07C211/29; C07C249/02; C07C251/24; (IPC1-7): C07C209/62; C07C209/52; C07C211/29; C07C249/02; C07C251/24
Domestic Patent References:
WO2002050056A12002-06-27
Foreign References:
Other References:
TOROK B. ET AL: "Synthesis of Chiral Trifluoromethylated Amines by Palladium-Catalyzed Diasteroselective Hydrogenation-Hydrogenolysis.", ADVANCED SYNTHESIS & CATALYSIS., vol. 345, no. 1+2, 2003, pages 165 - 168, XP002989156
PIRKLE W.H. ET AL: "Design of Chiral Derivatizing Agents for the Chromatographic Resolution of Optical Isomers. Asymetric Synthesis of Some Chiral Fluoroalkylated Amines.", JOURNAL OF ORGANIC CHEMISTRY., vol. 42, no. 14, 1977, pages 2436 - 2439, XP002989157
KATO K. ET AL: "Enzymatic resolution of 2,2,2,-trifluoro-1-arylethylamine derivatives by Pseudomonas fluorescens lipase in organic solvents.", JOURNAL OF MOLECULAR CATALYSIS B: ENZYMATIC., vol. 30, 3 August 2004 (2004-08-03), pages 61 - 68, XP002989158
See also references of EP 1721887A4
None
Attorney, Agent or Firm:
Hashimoto, Takeshi c/o Shiga, Patent Office (Ekisaikai Bldg. 1-29, Akashi-ch, Chuo-ku Tokyo 44, JP)
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