OPTICALLY ACTIVE 1,4-DIHYDROPYRIDINE COMPOUND AND PROCESS FOR PRODUCING THE SAME

Title:

OPTICALLY ACTIVE 1,4-DIHYDROPYRIDINE COMPOUND AND PROCESS FOR PRODUCING THE SAME

Document Type and Number:

WIPO Patent Application WO/1994/005637

Kind Code:

A1

Abstract:

A (4R)-3-(substituted aminoalkyl)oxycarbonyl-1,4-dihydro-2,6-dimethyl-4-(nitrophenyl)pyridine-5-carboxylic acid can be produced efficiently by the reaction of a bis(substituted aminoalkyl) 1,4-dihydro-2,6-dimethyl-4-(nitrophenyl)pyridine-3,5-dicarboxylate with a microorganism, or a product of treatment thereof, which can induce asymmetric hydrolysis and belongs to the genus Streptomyces, Paecilomyces, Botryodioplodia, Alternaria or Helminthosporium. This compound is extremely useful as an important intermediate for producing medicines useful for preventing or treating angina pectoris, hypertension and so forth.

Inventors:

ISSHIKI KUNIO (JP)
NAKASHIMA TAKASHI (JP)
YOSHIOKA TAKEO (JP)
TSUNEKAWA HIROSHI (JP)
ADACHI TAKASHI (JP)
OTA TOMOMI (JP)

Application Number:

PCT/JP1993/001222

Publication Date:

March 17, 1994

Filing Date:

August 31, 1993

Export Citation:

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Assignee:

MERCIAN CORP (JP)
TAISHO PHARMACEUTICAL CO LTD (JP)
ISSHIKI KUNIO (JP)
NAKASHIMA TAKASHI (JP)
YOSHIOKA TAKEO (JP)
TSUNEKAWA HIROSHI (JP)
ADACHI TAKASHI (JP)
OTA TOMOMI (JP)

International Classes:

C07D211/90; C12P17/12; C12P41/00; (IPC1-7): C07D211/90; C12P41/00

Foreign References:

JPH04299994A	1992-10-23
JPS6460398A	1989-03-07

Other References: