Title:
OPTICALLY ACTIVE AZABICYCLIC DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2020/045334
Kind Code:
A1
Abstract:
The present invention pertains to a compound represented by formula (1a) [wherein: p represents 1 or 2; R1 to R4 represent a hydrogen atom, etc.; and a to d represent 1 or 2] or a pharmaceutically acceptable salt thereof, said compound inhibiting the binding of an MLL-fusion protein, which carries a typical fusion partner gene such as AF4 or AF9 inducing MLL leukemia fused therewith, to menin and thus exerting an anticancer effect.
More Like This:
WO/2011/026579 | SUBSTITUTED AMINOQUINOXALINES AS TYROSINE THREONINE KINASE INHIBITORS |
JP7289301 | 4-azaindole compounds |
JP5977677 | Disposal or prevention of infection |
Inventors:
KAMIOKA SEIJI (JP)
BAN HITOSHI (JP)
SHIMADA NAOAKI (JP)
HIROSE WATARU (JP)
ARAKAWA AKIHIKO (JP)
YAMAZAKI KAZUTO (JP)
HIRA KENJIRO (JP)
BAN HITOSHI (JP)
SHIMADA NAOAKI (JP)
HIROSE WATARU (JP)
ARAKAWA AKIHIKO (JP)
YAMAZAKI KAZUTO (JP)
HIRA KENJIRO (JP)
Application Number:
PCT/JP2019/033234
Publication Date:
March 05, 2020
Filing Date:
August 26, 2019
Export Citation:
Assignee:
SUMITOMO DAINIPPON PHARMA CO LTD (JP)
International Classes:
A61K31/506; C07D471/10; A61K45/00; A61P35/00; A61P35/02; A61P43/00; C07D487/10
Domestic Patent References:
WO2018050686A1 | 2018-03-22 | |||
WO2017214367A1 | 2017-12-14 | |||
WO2019189732A1 | 2019-10-03 | |||
WO2017112768A1 | 2017-06-29 | |||
WO2017214367A1 | 2017-12-14 | |||
WO2018050686A1 | 2018-03-22 | |||
WO2008092049A1 | 2008-07-31 | |||
WO2015175707A1 | 2015-11-19 | |||
WO2003087067A1 | 2003-10-23 | |||
WO2000061562A1 | 2000-10-19 | |||
WO2009137733A1 | 2009-11-12 |
Foreign References:
JP2007510619A | 2007-04-26 |
Other References:
LOOK A. T, SCIENCE, vol. 278, no. 5340, 1997, pages 1059 - 1064
YOKOYAMA A ET AL., CELL, vol. 123, no. 2, 2005, pages 207 - 18
YOKOYAMA A ET AL., CANCER CELL, vol. 14, no. 1, 2008, pages 34 - 46
MALIK, R. ET AL., NATURE MEDICINE, vol. 21, no. 4, 2015, pages 344 - 352
IMACHO, H ET AL., BREAST CANCER RES TREAT., vol. 122, no. 2, 2010, pages 395 - 407
SVOBODA, L. K. ET AL., ONCOTARGRT, vol. 8, no. 1, 2017, pages 458 - 471
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 10, 1999, pages 2485 - 2490
J. MED. CHEM., vol. 53, no. 16, 2010, pages 6129 - 6152
J. MED. CHEM., vol. 59, no. 17, 2016, pages 7936 - 7949
J. ORG. CHEM., vol. 76, no. 10, 2011, pages 4149 - 4153
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 44, no. 10, 2009, pages 4179 - 4191
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 22, no. 24, 2012, pages 7456 - 74 60
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 12, no. 8, 2002, pages 1185 - 1187
BIOORGANIC & MEDICINAL CHEMISTRY, vol. 23, no. 1, 2015, pages 132 - 140
BIOORGANIC & MEDICINAL CHEMISTRY, vol. 19, no. 1, 2011, pages 211 - 220
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 23, no. 1, 1988, pages 53 - 62
TETRAHEDRON, vol. 62, no. 23, 2006, pages 5469 - 5473
J. MED. CHEM., vol. 23, no. 9, 1980, pages 1026 - 1031
J. MED, CHEM., vol. 53, no. 16, 2010, pages 6129 - 6152
J. ORG. CHEM., vol. 82, no. 17, 2017, pages 8933 - 8942
TETRAHEDRON, vol. 68, no. 29, 2012, pages 5845 - 5851
J. AM. CHEM. SOC., vol. 139, no. 16, 2017, pages 5998 - 6007
ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 45, no. 46, 2006, pages 7781 - 7786
J. CHEM. SOC., CHEM. COMMUN., 1988, pages 1599 - 1601
TETRAHEDRON LETTERS, vol. 43, 2002, pages 5957 - 5960
TETRAHEDRON ASYMMETRY, vol. 2, 1991, pages 1263 - 1282
TETRAHEDRON ASYMMETRY, vol. 27, 2016, pages 1062 - 1068
R. C. LAROCK: "Comprehensive Organic Transformation", 1989, JOHN WILEY & SONS, INC.
J. AM. CHEM. SOC., vol. 93, no. 12, 1971, pages 2897 - 2904
J. ORG. CHEM., vol. 37, no. 10, 1972, pages 1673 - 1674
J. ORG. CHEM., vol. 61, no. 11, 1996, pages 3849 - 3862
TETRAHEDRON, vol. 60, 2004, pages 7899 - 7906
TETRAHEDRON LETTERS, vol. 27, 1986, pages 2567 - 2570
SYNTHESIS, vol. 23, 2011, pages 3821 - 3826
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, 2013, pages 4493 - 4500
SYNTHETIC COMMUNICATIONS, vol. 28, 1998, pages 1743 - 1753
CHEMISTRY LETTERS, vol. 6, 1983, pages 875 - 878
JOURNAL OF ORGANIC CHEMISTRY, vol. 28, 1963, pages 6 - 16
TETRAHEDRON LETTERS, vol. 23, 1982, pages 477 - 480
SYNLETT, 1995, pages 443 - 444
SYNLETT, 1999, pages 96 - 98
TETRAHEDRON, vol. 56, 2000, pages 2779 - 2788
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 126, 2004, pages 14206 - 14216
SYNTHETIC COMMUNICATIONS, vol. 20, 1990, pages 839 - 847
ADVANCED SYNTHESIS & CATALYSIS, vol. 352, 2010, pages 153 - 162
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 132, 2010, pages 1236 - 1237
JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, 2006, pages 4409 - 4424
ADVANCED SYNTHESIS & CATALYSIS, vol. 357, 2015, pages 2803 - 2808
TETRAHEDRON LETTERS, vol. 47, no. 19, 2006, pages 3233 - 3237
ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 44, no. 34, 2005, pages 5516 - 5519
R.C.LAROCK: "Comprehensive Organic Transformations", 1999, JOHN WILEY & SONS INC.
See also references of EP 3845533A4
YOKOYAMA A ET AL., CELL, vol. 123, no. 2, 2005, pages 207 - 18
YOKOYAMA A ET AL., CANCER CELL, vol. 14, no. 1, 2008, pages 34 - 46
MALIK, R. ET AL., NATURE MEDICINE, vol. 21, no. 4, 2015, pages 344 - 352
IMACHO, H ET AL., BREAST CANCER RES TREAT., vol. 122, no. 2, 2010, pages 395 - 407
SVOBODA, L. K. ET AL., ONCOTARGRT, vol. 8, no. 1, 2017, pages 458 - 471
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 10, 1999, pages 2485 - 2490
J. MED. CHEM., vol. 53, no. 16, 2010, pages 6129 - 6152
J. MED. CHEM., vol. 59, no. 17, 2016, pages 7936 - 7949
J. ORG. CHEM., vol. 76, no. 10, 2011, pages 4149 - 4153
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 44, no. 10, 2009, pages 4179 - 4191
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 22, no. 24, 2012, pages 7456 - 74 60
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 12, no. 8, 2002, pages 1185 - 1187
BIOORGANIC & MEDICINAL CHEMISTRY, vol. 23, no. 1, 2015, pages 132 - 140
BIOORGANIC & MEDICINAL CHEMISTRY, vol. 19, no. 1, 2011, pages 211 - 220
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, vol. 23, no. 1, 1988, pages 53 - 62
TETRAHEDRON, vol. 62, no. 23, 2006, pages 5469 - 5473
J. MED. CHEM., vol. 23, no. 9, 1980, pages 1026 - 1031
J. MED, CHEM., vol. 53, no. 16, 2010, pages 6129 - 6152
J. ORG. CHEM., vol. 82, no. 17, 2017, pages 8933 - 8942
TETRAHEDRON, vol. 68, no. 29, 2012, pages 5845 - 5851
J. AM. CHEM. SOC., vol. 139, no. 16, 2017, pages 5998 - 6007
ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 45, no. 46, 2006, pages 7781 - 7786
J. CHEM. SOC., CHEM. COMMUN., 1988, pages 1599 - 1601
TETRAHEDRON LETTERS, vol. 43, 2002, pages 5957 - 5960
TETRAHEDRON ASYMMETRY, vol. 2, 1991, pages 1263 - 1282
TETRAHEDRON ASYMMETRY, vol. 27, 2016, pages 1062 - 1068
R. C. LAROCK: "Comprehensive Organic Transformation", 1989, JOHN WILEY & SONS, INC.
J. AM. CHEM. SOC., vol. 93, no. 12, 1971, pages 2897 - 2904
J. ORG. CHEM., vol. 37, no. 10, 1972, pages 1673 - 1674
J. ORG. CHEM., vol. 61, no. 11, 1996, pages 3849 - 3862
TETRAHEDRON, vol. 60, 2004, pages 7899 - 7906
TETRAHEDRON LETTERS, vol. 27, 1986, pages 2567 - 2570
SYNTHESIS, vol. 23, 2011, pages 3821 - 3826
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, 2013, pages 4493 - 4500
SYNTHETIC COMMUNICATIONS, vol. 28, 1998, pages 1743 - 1753
CHEMISTRY LETTERS, vol. 6, 1983, pages 875 - 878
JOURNAL OF ORGANIC CHEMISTRY, vol. 28, 1963, pages 6 - 16
TETRAHEDRON LETTERS, vol. 23, 1982, pages 477 - 480
SYNLETT, 1995, pages 443 - 444
SYNLETT, 1999, pages 96 - 98
TETRAHEDRON, vol. 56, 2000, pages 2779 - 2788
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 126, 2004, pages 14206 - 14216
SYNTHETIC COMMUNICATIONS, vol. 20, 1990, pages 839 - 847
ADVANCED SYNTHESIS & CATALYSIS, vol. 352, 2010, pages 153 - 162
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 132, 2010, pages 1236 - 1237
JOURNAL OF MEDICINAL CHEMISTRY, vol. 49, 2006, pages 4409 - 4424
ADVANCED SYNTHESIS & CATALYSIS, vol. 357, 2015, pages 2803 - 2808
TETRAHEDRON LETTERS, vol. 47, no. 19, 2006, pages 3233 - 3237
ANGEWANDTE CHEMIE, INTERNATIONAL EDITION, vol. 44, no. 34, 2005, pages 5516 - 5519
R.C.LAROCK: "Comprehensive Organic Transformations", 1999, JOHN WILEY & SONS INC.
See also references of EP 3845533A4
Attorney, Agent or Firm:
YAMAO, Norihito et al. (JP)
Download PDF: