Title:
OPTICALLY ACTIVE DIBENZYLAMINE DERIVATIVE, AND MANUFACTURING METHOD FOR SAME
Document Type and Number:
WIPO Patent Application WO/2011/152508
Kind Code:
A1
Abstract:
A substantially optically-pure (S)-trans-{4-[({2-[({1-[3,5-bis(trifluoromethyl) phenyl] ethyl}{5-[2-(methylsulfonyl) ethoxy] pyrimidine-2-yl} amino) methyl]-4-(trifluoromethyl) phenyl} (ethyl) amino) methyl] cyclohexyl} aceitic acid having the effect of reducing the amount of PCSK9 proteins and increasing the amount of LDL receptors, or a salt thereof, or a solvate thereof.
Inventors:
OHGIYA TADAAKI (JP)
MURAKAMI TAKESHI (JP)
MIYOSAWA KATSUTOSHI (JP)
SHIBUYA KIMIYUKI (JP)
YAMAZAKI KOICHI (JP)
KUSAKABE TAICHI (JP)
MURAKAMI TAKESHI (JP)
MIYOSAWA KATSUTOSHI (JP)
SHIBUYA KIMIYUKI (JP)
YAMAZAKI KOICHI (JP)
KUSAKABE TAICHI (JP)
Application Number:
PCT/JP2011/062751
Publication Date:
December 08, 2011
Filing Date:
June 03, 2011
Export Citation:
Assignee:
KOWA CO (JP)
OHGIYA TADAAKI (JP)
MURAKAMI TAKESHI (JP)
MIYOSAWA KATSUTOSHI (JP)
SHIBUYA KIMIYUKI (JP)
YAMAZAKI KOICHI (JP)
KUSAKABE TAICHI (JP)
OHGIYA TADAAKI (JP)
MURAKAMI TAKESHI (JP)
MIYOSAWA KATSUTOSHI (JP)
SHIBUYA KIMIYUKI (JP)
YAMAZAKI KOICHI (JP)
KUSAKABE TAICHI (JP)
International Classes:
C07D239/47; A61K31/505; A61P3/06; A61P9/10; A61P13/08; A61P13/12; A61P17/06; A61P19/10; A61P25/28; A61P27/02; A61P29/00; A61P31/12; A61P33/00; A61P35/00; A61P43/00
Domestic Patent References:
| WO2008129951A1 | 2008-10-30 | |||
| WO2009143633A1 | 2009-12-03 | |||
| WO2008129951A1 | 2008-10-30 |
Foreign References:
| JPH06509096A | 1994-10-13 |
Other References:
NORIAKI HIRAYAMA, YUKI KAGOBUTSU KESSHO SAKUSEI HANDBOOK, 25 July 2008 (2008-07-25), pages 130 - 135
"Nippon Rinsho", HYPERLIPIDEMIA, vol. 59, 2, 2001, pages 381 - 386
NAT. GENET., vol. 34, 2003, pages 154 - 156
N. ENGL. J. MED., vol. 354, 2006, pages 1264 - 1272
PROC. NATL. ACAD. SCI. USA, vol. 102, 2005, pages 5374 - 5379
PROC. NATL. ACAD. SCI. USA, vol. 106, 2009, pages 9820 - 9825
J. LIPID RES., vol. 48, 2007, pages 763 - 767
PROC. NATL.ACAD. SCI. USA, vol. 105, 2008, pages 11915 - 11920
ATHEROSCLEROSIS, vol. 201, no. 2, 2008, pages 266 - 73
MOL. CARCINOGEN., vol. 44, no. 3, 2005, pages 151 - 161
J. MOL. MED., vol. 83, 2005, pages 842 - 843
J. MOL. MED., vol. 83, 2005, pages 844 - 855
KOURIMATE S. ET AL., J. BIOL. CHEM., vol. 283, pages 9666
J. LIPID. RES., vol. 43, pages 805 - 814
See also references of EP 2578574A4
"Nippon Rinsho", HYPERLIPIDEMIA, vol. 59, 2, 2001, pages 381 - 386
NAT. GENET., vol. 34, 2003, pages 154 - 156
N. ENGL. J. MED., vol. 354, 2006, pages 1264 - 1272
PROC. NATL. ACAD. SCI. USA, vol. 102, 2005, pages 5374 - 5379
PROC. NATL. ACAD. SCI. USA, vol. 106, 2009, pages 9820 - 9825
J. LIPID RES., vol. 48, 2007, pages 763 - 767
PROC. NATL.ACAD. SCI. USA, vol. 105, 2008, pages 11915 - 11920
ATHEROSCLEROSIS, vol. 201, no. 2, 2008, pages 266 - 73
MOL. CARCINOGEN., vol. 44, no. 3, 2005, pages 151 - 161
J. MOL. MED., vol. 83, 2005, pages 842 - 843
J. MOL. MED., vol. 83, 2005, pages 844 - 855
KOURIMATE S. ET AL., J. BIOL. CHEM., vol. 283, pages 9666
J. LIPID. RES., vol. 43, pages 805 - 814
See also references of EP 2578574A4
Attorney, Agent or Firm:
SIKs & Co. (JP)
Patent business corporation patent firm Sykes (JP)
Patent business corporation patent firm Sykes (JP)
Download PDF:
Claims: