Title:
OPTICALLY ACTIVE PIPERAZINE COMPOUNDS, INTERMEDIATES FOR THE PREPARATION OF THE SAME AND PROCESSES FOR THE PREPARATION OF BOTH
Document Type and Number:
WIPO Patent Application WO/2001/002371
Kind Code:
A1
Abstract:
Optically active hydroxymethylpiperazines represented by general formula (1), useful as catalysts for asymmetric synthesis and so on; and intermediates for the preparation of the same, wherein R?1¿ is hydrogen, alkyl, cycloalkyl, optionally substituted aralkyl or the like; R?2¿ is hydrogen or a protecting silyl group; X is carbonyl or sulfonyl; and Y is optionally substituted alkyl, alkenyl, cycloalkyl, aryl or the like.
Inventors:
INOUE TSUTOMU (JP)
SATO DAISUKE (JP)
SATO DAISUKE (JP)
Application Number:
PCT/JP1999/003527
Publication Date:
January 11, 2001
Filing Date:
June 30, 1999
Export Citation:
Assignee:
NIPPON SODA CO (JP)
INOUE TSUTOMU (JP)
SATO DAISUKE (JP)
INOUE TSUTOMU (JP)
SATO DAISUKE (JP)
International Classes:
C07D241/04; (IPC1-7): C07D241/04
Foreign References:
| EP0398720A2 | 1990-11-22 |
Other References:
AAZDINE LAMOURNI ET AL.: "Design and Modeling of New Platelet-Activating Factor Antagonists. 1. Synthesis and Biological Activity of 1,4 Bis 3,4,5-Trimethoxybenzyl-2-substituted carbonyl and carbamoyl)oxy)methyl) Piperazines", J. MED. CHEM., vol. 36, no. 8, 1993, pages 990 - 1000, XP002920053
ALAN NAYLOR ET AL.: "A Potent New Class of K-Receptor Agonist: 4-Substituted 1-(Arylacetyl)-2-((dialkylamino)methyl) piperazines", J. MED. CHEM., vol. 36, no. 15, 1993, pages 2075 - 2083, XP002920054
MASSIMO FALORNI ET AL.: "Chiral Ligands Containing Heteroatoms. 11.1 Optically Active 2-Hydroxymethyl Piperazines as Catalysts in the Enatioselective Addition of Diethylzinc to Benzaldehyde", TETRAHEDRON: ASYMMETRY, vol. 4, no. 11, 1993, pages 2389 - 2398, XP002920055
MASSIMO FALORNI ET AL.: "An Efficient Stereocontrolled Synthesis of (R)-2-Carboxy-4-(3-phosphonopropyl) piperazine ((R)-CPP)", SYNLETT, no. 2, 1996, pages 143 - 144, XP002920056
KLAUS STINGL ET AL.: "Process for the Preparation of 2(S) Piperazinecarboxylic Acid by Continuos Resolution via Diastereomeric Salt Pairs", TETRAHEDRON: ASYMETRY, vol. 8, no. 7, 1997, pages 979 - 982, XP002920057
ALAN NAYLOR ET AL.: "A Potent New Class of K-Receptor Agonist: 4-Substituted 1-(Arylacetyl)-2-((dialkylamino)methyl) piperazines", J. MED. CHEM., vol. 36, no. 15, 1993, pages 2075 - 2083, XP002920054
MASSIMO FALORNI ET AL.: "Chiral Ligands Containing Heteroatoms. 11.1 Optically Active 2-Hydroxymethyl Piperazines as Catalysts in the Enatioselective Addition of Diethylzinc to Benzaldehyde", TETRAHEDRON: ASYMMETRY, vol. 4, no. 11, 1993, pages 2389 - 2398, XP002920055
MASSIMO FALORNI ET AL.: "An Efficient Stereocontrolled Synthesis of (R)-2-Carboxy-4-(3-phosphonopropyl) piperazine ((R)-CPP)", SYNLETT, no. 2, 1996, pages 143 - 144, XP002920056
KLAUS STINGL ET AL.: "Process for the Preparation of 2(S) Piperazinecarboxylic Acid by Continuos Resolution via Diastereomeric Salt Pairs", TETRAHEDRON: ASYMETRY, vol. 8, no. 7, 1997, pages 979 - 982, XP002920057
Attorney, Agent or Firm:
Tokai, Yusaku (Ltd. 2-1, Ohtemachi 2-chome Chiyoda-ku Tokyo, JP)
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