Title:
OPTICALLY ACTIVE PYRROLOPYRIDAZINE COMPOUNDS
Document Type and Number:
WIPO Patent Application WO/2000/077003
Kind Code:
A1
Abstract:
Optically active pyrrolopyridazine compounds having the general formula (I) or pharmacologically acceptable salts thereof: (wherein R?1¿ is alkyl; R?2¿ and R?3¿ are each independently alkyl; R?4¿ is optionally substituted aryl; and A is imino, oxygen, or sulfur). The compounds and the salts exhibit an excellent inhibitory activity against the secretion of gastric hydrochloric acid, a protective activity for the gastric mucus, and an excellent antimicrobial activity against Helicobacter pylori, and are useful as drugs, particularly preventive or therapeutic agents for ulcerative diseases.
Inventors:
HAGIHARA MASAHIKO (JP)
SHIBAKAWA NOBUHIKO (JP)
MATSUNOBU KEIJI (JP)
FUJIWARA HIROSHI (JP)
ITO KEIICHI (JP)
SHIBAKAWA NOBUHIKO (JP)
MATSUNOBU KEIJI (JP)
FUJIWARA HIROSHI (JP)
ITO KEIICHI (JP)
Application Number:
PCT/JP2000/003895
Publication Date:
December 21, 2000
Filing Date:
June 15, 2000
Export Citation:
Assignee:
SANKYO CO (JP)
UBE INDUSTRIES (JP)
HAGIHARA MASAHIKO (JP)
SHIBAKAWA NOBUHIKO (JP)
MATSUNOBU KEIJI (JP)
FUJIWARA HIROSHI (JP)
ITO KEIICHI (JP)
UBE INDUSTRIES (JP)
HAGIHARA MASAHIKO (JP)
SHIBAKAWA NOBUHIKO (JP)
MATSUNOBU KEIJI (JP)
FUJIWARA HIROSHI (JP)
ITO KEIICHI (JP)
International Classes:
A61K31/5025; A61P1/04; A61P31/04; C07D487/04; (IPC1-7): C07D487/04; A61K31/5025; A61P31/04; A61P1/04
Foreign References:
| EP0742218A1 | 1996-11-13 |
Other References:
See also references of EP 1186607A4
Attorney, Agent or Firm:
Nakamura, Minoru (Shin-Tokyo Bldg 3-1, Marunouchi 3-chom, Chiyoda-ku Tokyo, JP)
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