Title:
OPTICALLY ACTIVE QUATERNARY AMMONIUM SALT WITH AXIAL ASYMMETRY, PROCESS FOR PRODUCING THE SAME, AND APPLICATION TO ASYMMETRIC SYNTHESIS OF $g(a)-AMINO ACID DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2001/081349
Kind Code:
A1
Abstract:
A novel, optically active, quaternary ammonium salt with axial asymmetry which is useful as a phase-transfer catalyst with which a glycine derivative is stereoselectively alkylated to convert it into an optically active $g(a)-amino acid derivative. The quaternary ammonium salt is, for example, a compound represented by the formula (I). The quaternary ammonium salt is usable as a phase-transfer catalyst for stereoselectively alkylating a compound having a specific structure.
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Inventors:
MARUOKA KEIJI
Application Number:
PCT/JP2001/003373
Publication Date:
November 01, 2001
Filing Date:
April 19, 2001
Export Citation:
Assignee:
NAGASE & CO LTD (JP)
International Classes:
C07C15/58; C07C17/14; C07C17/26; C07C22/04; C07C25/22; C07C227/32; C07C249/02; C07C309/65; C07D223/14; C07D487/10; C07C229/36; C07C251/24; (IPC1-7): C07D487/10; C07B53/00; C07B61/00; C07C17/14; C07C17/263; C07C22/04; C07C25/18; C07C37/055; C07C39/14; C07C43/20; C07C249/02; C07C251/24; C07C309/65; C07D223/14; C07M7/00
Foreign References:
| JP2001048866A | 2001-02-20 |
Other References:
OOI T. ET AL.: "Facile synthesis of L-Dopa ... phase-transfer alkylation", TETRAHEDRON LETTERS, vol. 41, no. 43, October 2000 (2000-10-01), pages 8339 - 8342, XP002941728
OOI T. ET AL.: "Practical catalystic ... phase-transfer catalysis", J. AM. CHEM. SOC., vol. 122, no. 21, May 2000 (2000-05-01), pages 5228 - 5229, XP002941729
OOI T. ET AL.: "Molecular design of ... alpha-amino acids", J. AM. CHEM. SOC., vol. 121, no. 27, 1999, pages 6519 - 6520, XP002941730
See also references of EP 1277755A4
OOI T. ET AL.: "Practical catalystic ... phase-transfer catalysis", J. AM. CHEM. SOC., vol. 122, no. 21, May 2000 (2000-05-01), pages 5228 - 5229, XP002941729
OOI T. ET AL.: "Molecular design of ... alpha-amino acids", J. AM. CHEM. SOC., vol. 121, no. 27, 1999, pages 6519 - 6520, XP002941730
See also references of EP 1277755A4
Attorney, Agent or Firm:
Nanjo, Hiromichi (Nishitenma 3-chome Kita-ku, Osaka-shi Osaka, JP)
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