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Title:
OPTICALLY ACTIVE Α-TRIFLUORMETHYL-Β-AMINO ACID DERIVATIVE PRODUCTION METHOD
Document Type and Number:
WIPO Patent Application WO/2016/047644
Kind Code:
A1
Abstract:
Provided is a production method for an optically active α-trifluormethyl-β-amino acid derivative whereby: a compound indicated by general formula (1) and a compound indicated by general formula (2) are reacted in the presence of a copper-optically active phosphine complex comprising a copper compound and an optically active phosphine compound; and an optically active α-trifluormethyl-β-amino acid derivative indicated by general formula (3) is obtained.

Inventors:
SHIBASAKI, Masakatsu (14-23 Kamiosaki 3-chome, Shinagawa-k, Tokyo 21, 〒1410021, JP)
KUMAGAI, Naoya (14-23 Kamiosaki 3-chome, Shinagawa-k, Tokyo 21, 〒1410021, JP)
YIN, Liang (14-23 Kamiosaki 3-chome, Shinagawa-k, Tokyo 21, 〒1410021, JP)
Application Number:
JP2015/076816
Publication Date:
March 31, 2016
Filing Date:
September 18, 2015
Export Citation:
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Assignee:
MICROBIAL CHEMISTRY RESEARCH FOUNDATION (14-23, Kamiosaki 3-chome Shinagawa-k, Tokyo 21, 〒1410021, JP)
International Classes:
C07D213/75; B01J31/22; C07B53/00; C07B57/00; C07C269/06; C07C271/22; C07D471/04; C07B61/00
Foreign References:
JP2001139508A2001-05-22
JP2003260366A2003-09-16
Other References:
YIN, L. ET AL.: "Catalytic Generation of alpha-CF3 Enolate: Direct Catalytic Asymmetric Mannich- Type Reaction of alpha-CF3 Amide", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 136, no. 52, pages 17958 - 17961, XP055422391, ISSN: 0002-7863
SHIMADA, T. ET AL.: "First highly stereoselective synthesis of anti-alpha- trifluoromethyl-beta-amino acid derivatives", CHEMICAL COMMUNICATIONS, vol. 34, 2006, pages 3628 - 3630, XP055422403, ISSN: 1359-7345
YOKUKIN RIN ET AL.: "3 PA-085 Chiral Phosphine- Gin Shokubai ni yoru Alkenyl Trichloroacetates to Imines tono Fusei Mannich-gata Hanno", THE 92TH ANNUAL MEETING OF THE CHEMICAL SOCIETY OF JAPAN IN SPRING (2012) KOEN YOKOSHU IV, vol. 92, no. 4, 9 March 2012 (2012-03-09), pages 1697, XP009501404, ISSN: 0285-7626
See also references of EP 3199524A4
Attorney, Agent or Firm:
HIROTA, Koichi et al. (HIROTA, NAGARE & ASSOCIATES 4th Floor, TS Bldg., 1-24-10, Yoyogi, Shibuya-k, Tokyo 53, 〒1510053, JP)
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