Title:
OPTICALLY RESOLVED TROLOX INTERMEDIATE AND METHOD FOR PRODUCING SAME
Document Type and Number:
WIPO Patent Application WO/2021/167095
Kind Code:
A1
Abstract:
The present invention provides a method for chiral resolution of Trolox. The present disclosure relates to a method for producing a solid salt of a compound of formula I, wherein an amide-based solvent is added to a sample, which contains a compound of formula I, while being assumed to contain a compound of formula II, in the presence of an optical resolution agent.
Formula I: (R)-6-hydroxy-2, 5, 7, 8-tetramethylchroman-2-carboxylic acid (hereinafter referred to R Trolox)
Formula II: (S)-6-hydroxy-2, 5, 7, 8-tetramethylchroman-2-carboxylic acid (hereinafter referred to S Trolox)
Inventors:
KURODA KIICHI (JP)
SAWAMURA KIYOTO (JP)
TSUYUMINE SHINJIRO (JP)
SAWAMURA KIYOTO (JP)
TSUYUMINE SHINJIRO (JP)
Application Number:
PCT/JP2021/006465
Publication Date:
August 26, 2021
Filing Date:
February 19, 2021
Export Citation:
Assignee:
SUMITOMO DAINIPPON PHARMA CO LTD (JP)
PTC THERAPEUTICS INC (US)
PTC THERAPEUTICS INC (US)
International Classes:
C07D311/66; A61K31/122; A61P25/18; C07C231/12; C07C235/30
Domestic Patent References:
| WO2014168103A1 | 2014-10-16 | |||
| WO2009061744A2 | 2009-05-14 |
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| JP2020028614A | 2020-02-27 |
Other References:
HIROYUKI NOHIRA: "Separation of optical isomers (quarterly chemistry review no. 6)", KIKAN-KAGAKU-SÅSETSU = QUARTERLY CHEMICAL REVIEW, no. 6, 1 January 1989 (1989-01-01), JP, pages 45 - 54, XP009530687, ISSN: 1342-5722
BERGE S.M. ET AL.: "Pharmaceutical salts", PHARM. SCI., vol. 66, no. 1, January 1977 (1977-01-01), pages 1 - 19, XP002675560, DOI: 10.1002/jps.2600660104
SHELDRICK, G. M., ACTA CRYST., vol. A70, 2014, pages C1437
FLACK, H.D.BERNARDINELLI, J. APPL. CRYST., vol. 33, 2000, pages 114 - 1148
INTERNATIONAL TABLE IN CRYSTALLOGRAPHY, vol. C
CREAGH, D. C.HUBBELL, J.H.: "International Tables for Crystallography", vol. C, 1992, KLUWER ACADEMIC PUBLISHERS, pages: 200 - 206
IBERS, J. A.HAMILTON, W. C., ACTA CRYSTALLOGR., vol. 17, 1964, pages 781
SHELDRICK, G. M., ACTA CRYST, vol. A64, 2008, pages 112 - 122
BERGE S.M. ET AL.: "Pharmaceutical salts", PHARM. SCI., vol. 66, no. 1, January 1977 (1977-01-01), pages 1 - 19, XP002675560, DOI: 10.1002/jps.2600660104
SHELDRICK, G. M., ACTA CRYST., vol. A70, 2014, pages C1437
FLACK, H.D.BERNARDINELLI, J. APPL. CRYST., vol. 33, 2000, pages 114 - 1148
INTERNATIONAL TABLE IN CRYSTALLOGRAPHY, vol. C
CREAGH, D. C.HUBBELL, J.H.: "International Tables for Crystallography", vol. C, 1992, KLUWER ACADEMIC PUBLISHERS, pages: 200 - 206
IBERS, J. A.HAMILTON, W. C., ACTA CRYSTALLOGR., vol. 17, 1964, pages 781
SHELDRICK, G. M., ACTA CRYST, vol. A64, 2008, pages 112 - 122
Attorney, Agent or Firm:
YAMAMOTO, Shusaku et al. (JP)
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