Title:
OPTIMAL POLYMER MIXTURES FOR GASTRIC RETENTIVE TABLETS
Document Type and Number:
WIPO Patent Application WO2003035177
Kind Code:
A3
Abstract:
Unit dosage form tablets for the delivery of pharmaceuticals are formed of the pharmaceutical dispersed in a solid unitary matrix that is formed of a combination of poly(ethylene oxide) and hydroxypropyl methylcellulose. The combination offers unique benefits in terms of release rate control and reproducibility while allowing both swelling of the tablet to effect gastric retention and gradual disintegration of the tablet to clear the tablet from the gastrointestinal tract after release of the drug has occurred.
Inventors:
GUSLER GLORIA
BERNER BRET
CHAU MEI
PADUA AIMEE
BERNER BRET
CHAU MEI
PADUA AIMEE
Application Number:
PCT/US2002/033968
Publication Date:
August 14, 2003
Filing Date:
October 22, 2002
Export Citation:
Assignee:
DEPOMED INC (US)
International Classes:
A61K9/00; A61K9/20; A61K9/22; A61K47/34; A61K31/155; A61K31/19; A61K31/195; A61K31/4178; A61K31/496; A61K47/38; A61P1/00; A61P1/04; A61P1/06; A61P31/04; A61P35/00; (IPC1-7): A61K9/22; A61K47/34; A61K47/38
Foreign References:
| US4343789A | 1982-08-10 | |||
| US6120803A | 2000-09-19 | |||
| US5945125A | 1999-08-31 | |||
| US5783212A | 1998-07-21 |
Other References:
See also references of EP 1446106A4
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