Title:
OPTIMIZATION OF THE DESIGNING OF APPARATUS AND PROCESSES FOR MASS PRODUCTION OF MONODISPERSE BIODEGRADABLE POLYMER-BASED MICROSPHERES AND BIODEGRADABLE POLYMER-BASED DRUG DELIVERY SYSTEMS
Document Type and Number:
WIPO Patent Application WO/2018/088732
Kind Code:
A1
Abstract:
a method and an apparatus for a large-scale production of monodisperse microspheres and biodegradable polymer-based drug delivery systems and design optimization method for the apparatus are provided. The method uses a plurality of microchips, each microchip having at least a first pathway, a second pathway and an outlet, wherein the first pathway and the second pathway merge at a cross point being one end of the outlet, and the method comprises preparing a polymer-phase solution including a degradable polymer and a water-phase solution including a surfactant, having the polymer-phase solution flow through the first pathway, having the water-phase solution flow through the second pathway, gathering a mixed solution flowing out of the outlet, and collecting the microspheres by filtering out the water-phase solution.
Inventors:
KIM JU HEE (KR)
Application Number:
PCT/KR2017/011915
Publication Date:
May 17, 2018
Filing Date:
October 26, 2017
Export Citation:
Assignee:
INVENTAGE LAB INC (KR)
International Classes:
B01J13/04; A61K9/16; B01J19/00
Foreign References:
| US20060014894A1 | 2006-01-19 | |||
| JP2012011268A | 2012-01-19 | |||
| US20100092778A1 | 2010-04-15 | |||
| US20100247663A1 | 2010-09-30 | |||
| US4162282A | 1979-07-24 |
Other References:
See also references of EP 3570970A4
Attorney, Agent or Firm:
LEE, Chulhee (KR)
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