OPTOGENETIC MODULATION BY MULTI-CHARACTERISTIC OPSINS FOR VISION RESTORATION AND OTHER APPLICATIONS THEREOF

WIPO Patent Application WO/2018/106369

A3

This invention, in one aspect, relates generally to compositions and methods for modulating cellular activities by synthetic opsins. Further, the invention provides method for the use of synthetic opsins for vision restoration and other applications, wherein the amino acid sequence of the synthetic opsin is modified to provide enhanced light sensitivity, kinetics and ion-selectivity.

JPH0213391	PRODUCTION OF GAG PRECURSOR AS RECOMBINANT IN HIV, METHOD AND USE AS VACCINE FOR AIDS
JPH03504975	[Title of the Invention] A different-species functionality cell immunizing agent, a vaccine containing it, and directions for use for the same
WO/1990/005749	CONJUGATED POLYPEPTIDES AND METHODS FOR THEIR PREPARATION AND USE

MOHANTY SAMARENDRA (US)
BHATTACHARYA SULAGNA (US)

PCT/US2017/059922

July 19, 2018

November 03, 2017

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NANOSCOPE TECH LLC (US)

C07K14/00; A61K38/16; A61K48/00; A61P27/02; C07H21/04

WO2015157761A1	2015-10-15
WO2010011404A2	2010-01-28

BAMANN, C. ET AL.: "Spectral Characteristics of the Photocycle of Channelrhodopsin-2 and Its Implication for Channel Function", JOURNAL OF MOLECULAR BIOLOGY, vol. 375, no. 3, 1 November 2007 (2007-11-01), pages 686 - 694, XP022400110
KLAPOETKE, N. C. ET AL.: "Independent optical excitation of distinct neural populations", NATURE METHODS, vol. 11, no. 3, 2014, pages 338 - 346, XP055215656
See also references of EP 3535282A4

CHALKER, Daniel, J. et al. (US)

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