Title:
ORAL COMPOSITION CONTAINING INTERFERON-α
Document Type and Number:
WIPO Patent Application WO/2007/080942
Kind Code:
A1
Abstract:
An oral composition for preventing and/or treating periodontal diseases containing interferon-α (IFN-α) as an active ingredient is provided. By orally administrating the composition of the invention, the number of causative microorganisms of periodontal diseases can be reduced. IFN-α in the invention can exhibit a sufficient effect by administration of a small amount thereof. Further, by blending it in an animal feed, the composition of the invention can be easily given to an animal such as a dog.
Inventors:
YOSHIOKA KUNIAKI (JP)
SATO KO (JP)
GOTANDA TORU (JP)
ITO AKIRA (JP)
ISOGAI EMIKO (JP)
TAKEHARA KAZUAKI (JP)
MAEHARA NOBUTOSHI (JP)
SATO KO (JP)
GOTANDA TORU (JP)
ITO AKIRA (JP)
ISOGAI EMIKO (JP)
TAKEHARA KAZUAKI (JP)
MAEHARA NOBUTOSHI (JP)
Application Number:
PCT/JP2007/050281
Publication Date:
July 19, 2007
Filing Date:
January 12, 2007
Export Citation:
Assignee:
KITASATO INST (JP)
NAT INST OF ADVANCED IND SCIEN (JP)
YOSHIOKA KUNIAKI (JP)
SATO KO (JP)
GOTANDA TORU (JP)
ITO AKIRA (JP)
ISOGAI EMIKO (JP)
TAKEHARA KAZUAKI (JP)
MAEHARA NOBUTOSHI (JP)
NAT INST OF ADVANCED IND SCIEN (JP)
YOSHIOKA KUNIAKI (JP)
SATO KO (JP)
GOTANDA TORU (JP)
ITO AKIRA (JP)
ISOGAI EMIKO (JP)
TAKEHARA KAZUAKI (JP)
MAEHARA NOBUTOSHI (JP)
International Classes:
A61K38/21; A23G4/00; A23G4/06; A23L33/17; A23L33/18; A61K9/06; A61K9/20; A61K9/68; A61P1/02; C12N15/09
Foreign References:
| JPH03504375A | 1991-09-26 | |||
| JP2004018519A | 2004-01-22 | |||
| JP2005522203A | 2005-07-28 | |||
| JP2002034590A | 2002-02-05 | |||
| JP2002034577A | 2002-02-05 | |||
| JP2001342199A | 2001-12-11 | |||
| JPH01239498A | 1989-09-25 | |||
| JP2005089301A | 2005-04-07 | |||
| US4695623A | 1987-09-22 | |||
| US4897471A | 1990-01-30 | |||
| US5985265A | 1999-11-16 | |||
| US5382657A | 1995-01-17 | |||
| US5559213A | 1996-09-24 | |||
| US6177074B1 | 2001-01-23 | |||
| US5951974A | 1999-09-14 | |||
| US5981709A | 1999-11-09 |
Other References:
KASER A. ET AL.: "Interferon-alpha in Inflammation and Immunity", CELLULAR AND MOLECULAR BIOLOGY, vol. 47, no. 4, 2001, pages 609 - 617, XP008083159
GUTTERMAN J.U.: "Cytokine Therapeutics: Lessons from Interferon alpha", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 91, no. 4, 1994, pages 1198 - 1205, XP002129420
PIHLSTROM B.L. ET AL.: "Periodontal diseases", THE LANCET, vol. 366, 2005, pages 1809 - 1820, XP005171144
See also references of EP 1985303A4
CUMMINS, M. J., ARTHRITIS RHEUM., vol. 49, no. 4, 2003, pages 585 - 593
SHIOZAWA, S., J. INTERFERON CYTOKINE RES., vol. 18, no. 4, 1998, pages 255 - 262
SHIP, J. A., J. INTERFERON CYTOKINE RES., vol. 19, no. 8, 1999, pages 943 - 951
GILGER, B. C., J. INTERFERON CYTOKINE RES., vol. 19, no. 8, 1999, pages 901 - 905
SATOH, Y., J. INTERFERON CYTOKINE RES., vol. 19, no. 8, 1999, pages 887 - 894
PALOMBA, M., CLIN. TER., vol. 151, no. 1, 2000, pages 59 - 61
LECCIONES, J. A., J. INTERFERON CYTOKINE RES., vol. 18, no. 9, 1998, pages 647 - 652
LECCE, J. G., MOL. BIOTHER., vol. 2, no. 4, 1990, pages 211 - 216
YOUNG, A. S., PARASITOLOGY, vol. 101, no. 2, 1990, pages 201 - 209
TOMPKINS, W. A., J. INTERFERON CYTOKINE RES., vol. 19, 1999, pages 817 - 828
OHTSUKA, H., J. VET. MED. SCI., vol. 68, no. 10, 2006, pages 1063 - 1067
"Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
"Current Protocols in Molecular Biology", JOHN WILEY & SONS, INC.
DAHIYAT; MAYO, SCIENCE, vol. 278, 1997, pages 8287
KUNKEL, PROC. NAT. ACAD. SCI. U.S.A., vol. 82, 1985, pages 488 - 492
ALTSCHUL S. F. ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
ODELL ET AL., NATURE, vol. 313, 1985, pages 810
ZHANG ET AL., PLANT CELL, vol. 3, 1991, pages 1155
CORNEJO ET AL., PLANT MOL. BIOL., vol. 23, 1993, pages 567
VISSER ET AL., THEOR. APPL. GENET, vol. 78, 1989, pages 594
HIEI, Y.; KOMARI, T.; KUBO, T.: "Transformation of rice mediated by Agrobacterium tumefaciens", PLANT MOL. BIOL., vol. 35, no. 1-2, 1997, pages 205 - 18
ISHIDA, Y.; SAITO, H.; OHTA, S.; HIEI, Y; KOMARI T.; KUMASHIRO T.: "High efficiency transformation of maize (Zea mays L.) mediated by Agrobacterium tumefaciens", NAT. BIOTECHNOL., vol. 14, no. 6, June 1996 (1996-06-01), pages 745 - 50
SHIMAMOTO, K.; TERADA, R.; IZAWA, T. ET AL.: "Fertile transgenic rice plants regenerated from transformed protoplasts", NATURE, vol. 338, 1989, pages 274 - 276
ASAO, H.; Y NISHIZAWA; S. ARAI; T. SATO; M. HIRAI; K. YOSHIDA; A. SHINMYO; T. HIBI: "Enhanced resistance against a fungal pathogen Sphaerotheca humuli in transgenic strawberry expressing a rice chitinase gene", PLANT BIOTECHNOLOGY, vol. 14, no. 3, 1997, pages 145 - 149
J. VET. MED. SCI., vol. 58, no. 1, 1996, pages 23 - 27
J. GEN. VIROL., vol. 68, 1987, pages 1233 - 1250
ACTA ODONT. SCAND., vol. 21, 1963, pages 533 - 551
GUTTERMAN J.U.: "Cytokine Therapeutics: Lessons from Interferon alpha", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 91, no. 4, 1994, pages 1198 - 1205, XP002129420
PIHLSTROM B.L. ET AL.: "Periodontal diseases", THE LANCET, vol. 366, 2005, pages 1809 - 1820, XP005171144
See also references of EP 1985303A4
CUMMINS, M. J., ARTHRITIS RHEUM., vol. 49, no. 4, 2003, pages 585 - 593
SHIOZAWA, S., J. INTERFERON CYTOKINE RES., vol. 18, no. 4, 1998, pages 255 - 262
SHIP, J. A., J. INTERFERON CYTOKINE RES., vol. 19, no. 8, 1999, pages 943 - 951
GILGER, B. C., J. INTERFERON CYTOKINE RES., vol. 19, no. 8, 1999, pages 901 - 905
SATOH, Y., J. INTERFERON CYTOKINE RES., vol. 19, no. 8, 1999, pages 887 - 894
PALOMBA, M., CLIN. TER., vol. 151, no. 1, 2000, pages 59 - 61
LECCIONES, J. A., J. INTERFERON CYTOKINE RES., vol. 18, no. 9, 1998, pages 647 - 652
LECCE, J. G., MOL. BIOTHER., vol. 2, no. 4, 1990, pages 211 - 216
YOUNG, A. S., PARASITOLOGY, vol. 101, no. 2, 1990, pages 201 - 209
TOMPKINS, W. A., J. INTERFERON CYTOKINE RES., vol. 19, 1999, pages 817 - 828
OHTSUKA, H., J. VET. MED. SCI., vol. 68, no. 10, 2006, pages 1063 - 1067
"Molecular Cloning: A Laboratory Manual", 1989, COLD SPRING HARBOR LABORATORY PRESS
"Current Protocols in Molecular Biology", JOHN WILEY & SONS, INC.
DAHIYAT; MAYO, SCIENCE, vol. 278, 1997, pages 8287
KUNKEL, PROC. NAT. ACAD. SCI. U.S.A., vol. 82, 1985, pages 488 - 492
ALTSCHUL S. F. ET AL., J. MOL. BIOL., vol. 215, 1990, pages 403 - 410
ODELL ET AL., NATURE, vol. 313, 1985, pages 810
ZHANG ET AL., PLANT CELL, vol. 3, 1991, pages 1155
CORNEJO ET AL., PLANT MOL. BIOL., vol. 23, 1993, pages 567
VISSER ET AL., THEOR. APPL. GENET, vol. 78, 1989, pages 594
HIEI, Y.; KOMARI, T.; KUBO, T.: "Transformation of rice mediated by Agrobacterium tumefaciens", PLANT MOL. BIOL., vol. 35, no. 1-2, 1997, pages 205 - 18
ISHIDA, Y.; SAITO, H.; OHTA, S.; HIEI, Y; KOMARI T.; KUMASHIRO T.: "High efficiency transformation of maize (Zea mays L.) mediated by Agrobacterium tumefaciens", NAT. BIOTECHNOL., vol. 14, no. 6, June 1996 (1996-06-01), pages 745 - 50
SHIMAMOTO, K.; TERADA, R.; IZAWA, T. ET AL.: "Fertile transgenic rice plants regenerated from transformed protoplasts", NATURE, vol. 338, 1989, pages 274 - 276
ASAO, H.; Y NISHIZAWA; S. ARAI; T. SATO; M. HIRAI; K. YOSHIDA; A. SHINMYO; T. HIBI: "Enhanced resistance against a fungal pathogen Sphaerotheca humuli in transgenic strawberry expressing a rice chitinase gene", PLANT BIOTECHNOLOGY, vol. 14, no. 3, 1997, pages 145 - 149
J. VET. MED. SCI., vol. 58, no. 1, 1996, pages 23 - 27
J. GEN. VIROL., vol. 68, 1987, pages 1233 - 1250
ACTA ODONT. SCAND., vol. 21, 1963, pages 533 - 551
Attorney, Agent or Firm:
SHIMIZU, Hatsushi et al. (1-1-1 Oroshi-mach, Tsuchiura-shi Ibaraki 47, JP)
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