Title:
ORAL DELIVERY OF THERAPEUTIC AGENTS
Document Type and Number:
WIPO Patent Application WO/2023/065231
Kind Code:
A1
Abstract:
Provided herein are pharmaceutical compositions comprising therapeutic agent (s) and functional excipients that can enhance oral bioavailability of the therapeutic agent (s). Also provided herein are methods of preparing the pharmaceutical composition and methods of using the same for treating various diseases or disorders such as type-2 diabetes.
Inventors:
DINH STEVEN (CN)
TANG HUADONG (CN)
LIANG WENFEI (CN)
TANG HUADONG (CN)
LIANG WENFEI (CN)
Application Number:
PCT/CN2021/125360
Publication Date:
April 27, 2023
Filing Date:
October 21, 2021
Export Citation:
Assignee:
GUANGZHOU DAZHOU BIOMEDICINE LTD (CN)
International Classes:
A61K38/26; A61P3/10
Domestic Patent References:
| WO2014177683A1 | 2014-11-06 | |||
| WO2016120380A1 | 2016-08-04 | |||
| WO2007121318A2 | 2007-10-25 |
Foreign References:
| CN108653234A | 2018-10-16 | |||
| US20200000728A1 | 2020-01-02 | |||
| US20160067184A1 | 2016-03-10 |
Other References:
CAROLINE TWAROG, SARINJ FATTAH, JOANNE HEADE, SAM MAHER, ELIAS FATTAL, DAVID J. BRAYDEN: "Intestinal Permeation Enhancers for Oral Delivery of Macromolecules: A Comparison between Salcaprozate Sodium (SNAC) and Sodium Caprate (C10)", PHARMACEUTICS, vol. 11, no. 2, pages 78, XP055634457, DOI: 10.3390/pharmaceutics11020078
TWAROG，C. ET AL.: "A head-to-head Caco-2 assay comparison of the mechanisms of action of the intestinal permeation enhancers: SNAC and sodium caprate (C10).", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS., vol. 152, 6 May 2020 (2020-05-06), pages 95 - 107, XP086183237, DOI: 10.1016/j.ejpb.2020.04.023
TWAROG，C. ET AL.: "A head-to-head Caco-2 assay comparison of the mechanisms of action of the intestinal permeation enhancers: SNAC and sodium caprate (C10).", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS., vol. 152, 6 May 2020 (2020-05-06), pages 95 - 107, XP086183237, DOI: 10.1016/j.ejpb.2020.04.023
Attorney, Agent or Firm:
ZHONGZI LAW OFFICE (CN)
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