ORAL DISINTEGRATING TABLET HAVING MASKED BITTER TASTE AND METHOD FOR PRODUCTION THEREOF

WIPO Patent Application WO/2008/018371

A1

Provided is an oral disintegrating tablet comprising mitiglinide calcium hydrate, which shows reduced bitter taste and rapid disintegrating properties in an oral cavity and can be dissolved in a digestive tract rapidly. The oral disintegrating tablet comprises a) mitiglinide calcium hydrate, b) crystalline cellulose, c) at least one member selected from the group consisting of an aminoalkyl methacrylate copolymer E, polyvinylacetal diethylaminoacetate, an ethyl acrylate/methyl methacrylate copolymer and ethylcellulose as a masking agent, d) a sugar or a sugar alcohol, and e) at least one member selected from corn starch and partially gelatinized starch, and has masked bitter taste.

MIMURA, Kazuki (Kissei Pharmaceutical Co. Ltd., 4365-1, Hotaka-Kashiwabara, Azumino-sh, Nagano 04, 3998304, JP)
三村和樹 (〒04 長野県安曇野市穂高柏原４３６５－１ キッセイ薬品工業株式会社中央研究所内 Nagano, 3998304, JP)
TAKEDA, Yasuhiro (Kissei Pharmaceutical Co. Ltd., 4365-1, Hotaka-Kashiwabara, Azumino-sh, Nagano 04, 3998304, JP)

JP2007/065228

February 14, 2008

August 03, 2007

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Kissei Pharmaceutical Co., Ltd. (19-48, Yoshino Matsumoto-sh, Nagano 10, 3998710, JP)
キッセイ薬品工業株式会社 (〒10 長野県松本市芳野１９－４８ Nagano, 3998710, JP)
MIMURA, Kazuki (Kissei Pharmaceutical Co. Ltd., 4365-1, Hotaka-Kashiwabara, Azumino-sh, Nagano 04, 3998304, JP)
三村和樹 (〒04 長野県安曇野市穂高柏原４３６５－１ キッセイ薬品工業株式会社中央研究所内 Nagano, 3998304, JP)

A61K31/4035; A61K9/20; A61K47/10; A61K47/26; A61K47/32; A61K47/36; A61K47/38; A61P3/10

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