Title:
ORAL DRUG, TUMOR SUPPRESSION AID, AND PET THERAPEUTIC DIET
Document Type and Number:
WIPO Patent Application WO/2020/250980
Kind Code:
A1
Abstract:
The present invention includes a poly(R)-3-β-hydroxybutyric acid powder having a weight average molecular weight of 10,000 to 700,000, inclusive. A poly(R)-3-β-hydroxybutyric acid powder having a purity of 70% or greater and a weight average molecular weight of 10,000 to 590,000, inclusive, may be included. A poly(R)-3-β-hydroxybutyric acid powder having a purity of 90% or greater and a weight average molecular weight of 10,000 to 590,000, inclusive, may be included. An oral drug for increasing the concentration of ketone bodies in blood, being a poly(R)-3-β-hydroxybutyric acid powder having a weight average molecular weight of 10,000 to 700,000, inclusive, may be included. According to the present invention, a state in which the concentration of ketone bodies in blood is increased is maintained for a longer period of time.
More Like This:
Inventors:
SATOH TAKUMI (JP)
YAMASHITA TADASHI (JP)
NAGANE MASAKI (JP)
YAMASHITA TADASHI (JP)
NAGANE MASAKI (JP)
Application Number:
PCT/JP2020/023042
Publication Date:
December 17, 2020
Filing Date:
June 11, 2020
Export Citation:
Assignee:
SATOH TAKUMI (JP)
SCHOOL CORPORATION AZABU VETERINARY MEDICINE EDUCATIONAL INST (JP)
SCHOOL CORPORATION AZABU VETERINARY MEDICINE EDUCATIONAL INST (JP)
International Classes:
A61P3/00; A23K20/105; A23K50/40; A23L33/10; A23L33/21; A61K9/14; A61K9/20; A61K31/765; A61K33/24; A61K35/74; A61P3/04; A61P3/06; A61P25/28; A61P29/00; A61P35/00; C08G63/06; C12N1/20; C12N9/20; C12N9/50; C12P7/26; C12P7/62
Domestic Patent References:
| WO2019035486A1 | 2019-02-21 | |||
| WO2005021013A1 | 2005-03-10 | |||
| WO2008120778A1 | 2008-10-09 |
Other References:
DUAN, YAFEI ET AL.: "Effects of dietary poly-beta-hydroxybutyrate (PHB) on microbiota composition and the mTOR signaling pathway in the intestines of Litopenaeus vannamei", JORNAL OF MICROBIOLOGY, vol. 55, no. 12, 2017, pages 946 - 954, XP036437494, DOI: 10.1007/s12275-017-7273-y
SINGH NAGENDRA, GURAV ASHISH, SIVAPRAKASAM SATHISH, BRADY EVAN, PADIA RAVI, SHI HUIDONG, THANGARAJU MUTHUSAMY, PRASAD PUTTUR D., M: "Activation of Gprl09a, Receptor for Niacin and the Commensal Metabolite Butylate", SUPPRESSES COLONIC INFLAMMATION AND CARCINOGENESIS, IMMUNITY, vol. 40, no. 1, 16 January 2014 (2014-01-16), pages 128 - 139, XP055771580, DOI: 10.1016/j.imuni. 2013.12.00 7
WOOLF ERIC C., SYED NELOFER, SCHECK ADRIENNE C.: "Tumor Metabolism, the Ketogenic Diet and beta- hydroxybutyrate: Novel Approaches to Adjuvant Brain Tumor Therapy", FRONTIERS IN MOLECULAR NEUROSCIENCE, vol. 9, no. 122, 16 November 2016 (2016-11-16), pages 1 - 11, XP055771581
MOHAMMED G ABDELWAHAB; KATHRYN E FENTON; MARK C PREUL; JONG M RHO; ANDREW LYNCH; PHILLIP STAFFORD; ADRIENNE C SCHECK: "The Ketogenic Diet Is an Effective Adjuvant to Radiation Therapy for the Treatment of Malignant Glioma", PLOS ONE, vol. 7, no. 5, 1 May 2012 (2012-05-01), pages e36197, XP002717707, DOI: 10.1371/ journal. pone. 0036197
CAVALERI FRANCO, BASHAR EMRAN: "Potential Synergies of beta-Hydroxybutyrate and Butyrate on the Modulation, Inflammation, Cognition, and General Health", JOURNAL OF NUTRITION AND METABOLISM, vol. 2018, no. 7195760, 1 April 2018 (2018-04-01), pages 1 - 14, XP055771583, DOI: 10.1155/2018/7195760
NEWMAN JOHN C, VERDIN ERIC: "beta-Hydroxybutyrate: A signaling Metabolite", THE ANNUAL REVIEW OF NUTRITION, vol. 37, 21 August 2017 (2017-08-21), pages 51 - 76, XP055771586, DOI: 10.1146/annurev-nutr-071816-064916
SINGH NAGENDRA, GURAV ASHISH, SIVAPRAKASAM SATHISH, BRADY EVAN, PADIA RAVI, SHI HUIDONG, THANGARAJU MUTHUSAMY, PRASAD PUTTUR D., M: "Activation of Gprl09a, Receptor for Niacin and the Commensal Metabolite Butylate", SUPPRESSES COLONIC INFLAMMATION AND CARCINOGENESIS, IMMUNITY, vol. 40, no. 1, 16 January 2014 (2014-01-16), pages 128 - 139, XP055771580, DOI: 10.1016/j.imuni. 2013.12.00 7
WOOLF ERIC C., SYED NELOFER, SCHECK ADRIENNE C.: "Tumor Metabolism, the Ketogenic Diet and beta- hydroxybutyrate: Novel Approaches to Adjuvant Brain Tumor Therapy", FRONTIERS IN MOLECULAR NEUROSCIENCE, vol. 9, no. 122, 16 November 2016 (2016-11-16), pages 1 - 11, XP055771581
MOHAMMED G ABDELWAHAB; KATHRYN E FENTON; MARK C PREUL; JONG M RHO; ANDREW LYNCH; PHILLIP STAFFORD; ADRIENNE C SCHECK: "The Ketogenic Diet Is an Effective Adjuvant to Radiation Therapy for the Treatment of Malignant Glioma", PLOS ONE, vol. 7, no. 5, 1 May 2012 (2012-05-01), pages e36197, XP002717707, DOI: 10.1371/ journal. pone. 0036197
CAVALERI FRANCO, BASHAR EMRAN: "Potential Synergies of beta-Hydroxybutyrate and Butyrate on the Modulation, Inflammation, Cognition, and General Health", JOURNAL OF NUTRITION AND METABOLISM, vol. 2018, no. 7195760, 1 April 2018 (2018-04-01), pages 1 - 14, XP055771583, DOI: 10.1155/2018/7195760
NEWMAN JOHN C, VERDIN ERIC: "beta-Hydroxybutyrate: A signaling Metabolite", THE ANNUAL REVIEW OF NUTRITION, vol. 37, 21 August 2017 (2017-08-21), pages 51 - 76, XP055771586, DOI: 10.1146/annurev-nutr-071816-064916
Attorney, Agent or Firm:
IZUMI Michihiro (JP)
Download PDF:
Previous Patent: ORGANIC LIGHT EMISSION ELEMENT, LAMINATION BODY, AND LIGHT EMISSION METHOD
Next Patent: SOLID-STATE BATTERY
Next Patent: SOLID-STATE BATTERY