Title:
ORAL NANOPARTICLES FOR BIOACTIVE COMPOUND, AND METHOD OF PREPARING SAME
Document Type and Number:
WIPO Patent Application WO/2022/211481
Kind Code:
A1
Abstract:
The present invention relates to: oral nanoparticles for enabling oral administration of a bioactive compound which is typically administered by injection due to having low bioavailability attributable to issues with solubility, disintegration in the digestive tract, and intestinal permeability; a method of formulating the oral nanoparticles; and a use of the oral nanoparticles. In addition, the present invention relates to: oral nanoparticles capable of maintaining or protecting the balance in the gut microbiome by minimizing the exposure of the gut microbiome to a bioactive compound; a formulation; and a use of same.
Inventors:
HONG SEONG TSHOOL (KR)
KIM HYEON JIN (US)
HONG JINNY (US)
ZHAI CHONGKAI (KR)
WANG MINGDA (KR)
KIM HYEON JIN (US)
HONG JINNY (US)
ZHAI CHONGKAI (KR)
WANG MINGDA (KR)
Application Number:
PCT/KR2022/004490
Publication Date:
October 06, 2022
Filing Date:
March 30, 2022
Export Citation:
Assignee:
SNJ PHARMA INC (US)
HONG SEONG TSHOOL (KR)
HONG SEONG TSHOOL (KR)
International Classes:
A61K9/51; A61K9/00; A61K31/155; A61K31/167; A61K31/513; A61K31/675; A61P1/00; A61P43/00
Domestic Patent References:
| WO2020252375A1 | 2020-12-17 | |||
| WO2021030411A1 | 2021-02-18 |
Foreign References:
| KR101741977B1 | 2017-05-31 | |||
| US20200214989A1 | 2020-07-09 | |||
| US7060708B2 | 2006-06-13 | |||
| US7144877B2 | 2006-12-05 | |||
| US7598235B2 | 2009-10-06 | |||
| US7678782B2 | 2010-03-16 | |||
| US7736679B2 | 2010-06-15 | |||
| US20190247313A1 | 2019-08-15 | |||
| US20200009067A1 | 2020-01-09 |
Other References:
SAMSTEIN, R.M. PERICA, K. BALDERRAMA, F. LOOK, M. FAHMY, T.M.: "The use of deoxycholic acid to enhance the oral bioavailability of biodegradable nanoparticles", BIOMATERIALS, ELSEVIER, AMSTERDAM, NL, vol. 29, no. 6, 19 November 2007 (2007-11-19), AMSTERDAM, NL , pages 703 - 708, XP022371123, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2007.10.026
"Remington's Pharmaceutical Sciences", 1995
"Remington's Pharmaceutical Sciences", 1995
Attorney, Agent or Firm:
HAEDAM IP GROUP (KR)
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