Title:
ORAL PHARMACEUTICAL COMPOSITION COMPRISING TERIPARATIDE AND METHOD FOR PREPARING SAME
Document Type and Number:
WIPO Patent Application WO/2021/045345
Kind Code:
A1
Abstract:
The present invention relates to an oral pharmaceutical composition comprising an ion-bonding complex consisting of teriparatide, deoxycholic acid, Nα-deoxycholyl-L-lysyl-methylester (DCK) and D-α-tocopherol polyethylene glycol 1000 succinate, and a method for preparing same. As the oral pharmaceutical composition according to the present invention can increase intestinal membrane permeability and oral administration bioavailability of teriparatide and improve patient compliance, the oral pharmaceutical composition is useful for treating osteoporosis.
Inventors:
CHOI YOUNG KWEON (KR)
CHANG KWAN YOUNG (KR)
LEE JAE BUM (KR)
KANG SEOHEE (KR)
SEO YUSEON (KR)
NA HYERIM (KR)
CHANG KWAN YOUNG (KR)
LEE JAE BUM (KR)
KANG SEOHEE (KR)
SEO YUSEON (KR)
NA HYERIM (KR)
Application Number:
PCT/KR2020/006255
Publication Date:
March 11, 2021
Filing Date:
May 13, 2020
Export Citation:
Assignee:
ICURE BNP CO LTD (KR)
International Classes:
A61K47/54; A61K9/00; A61K9/107; A61K9/20; A61K9/28; A61K38/29; A61P19/10
Foreign References:
| KR101796604B1 | 2017-11-10 | |||
| KR20190070653A | 2019-06-21 | |||
| US20080119408A1 | 2008-05-22 | |||
| KR101895237B1 | 2018-09-07 | |||
| DK2004000482W | 2004-07-05 | |||
| CZ2012000025W | 2012-03-16 | |||
| IL2017050920W | 2017-08-17 |
Other References:
GUO, Y. ET AL: "The applications of Vitamin ETPGS indrug delivery", EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, vol. 49, no. 2, 26 February 2013 (2013-02-26), pages 175 - 186, XP028531143
HWANG, S. R.: "Preparation and in vivo evaluation of an orally available enteric-microencapsulated parathyroid hormone (1-34)-deoxycholic acid nanocomplex", INTERNATIONAL JOURNAL OF NANOMEDICINE, vol. 11, 31 August 2016 (2016-08-31), pages 4 231 - 4246, XP055799519
PANGENI, R. ET AL: "Multiple nanoemulsion system for an oral combinational delivery of oxaliplatin and 5-fluorouracil: preparation and in vivo evaluation", INTERNATIONAL JOURNAL OF NANOMEDICINE, vol. 11, 30 November 2016 (2016-11-30), pages 6379 - 6399, XP055558169
QIAO, H.: "Fabrication and in vitro/in vivo evaluation of amorphous andrographolide nanosuspensions stabilized by d-alpha-tocopheryl polyethylene glycol 1000 succinate/sodium lauryl sulfate", INTERNATIONAL JOURNAL OF NANOMEDICINE, vol. 12, 7 February 2017 (2017-02-07), pages 1033 - 1046, XP055799521
See also references of EP 4026566A4
HWANG, S. R.: "Preparation and in vivo evaluation of an orally available enteric-microencapsulated parathyroid hormone (1-34)-deoxycholic acid nanocomplex", INTERNATIONAL JOURNAL OF NANOMEDICINE, vol. 11, 31 August 2016 (2016-08-31), pages 4 231 - 4246, XP055799519
PANGENI, R. ET AL: "Multiple nanoemulsion system for an oral combinational delivery of oxaliplatin and 5-fluorouracil: preparation and in vivo evaluation", INTERNATIONAL JOURNAL OF NANOMEDICINE, vol. 11, 30 November 2016 (2016-11-30), pages 6379 - 6399, XP055558169
QIAO, H.: "Fabrication and in vitro/in vivo evaluation of amorphous andrographolide nanosuspensions stabilized by d-alpha-tocopheryl polyethylene glycol 1000 succinate/sodium lauryl sulfate", INTERNATIONAL JOURNAL OF NANOMEDICINE, vol. 12, 7 February 2017 (2017-02-07), pages 1033 - 1046, XP055799521
See also references of EP 4026566A4
Attorney, Agent or Firm:
DAWOOL PATENT AND LAW FIRM (KR)
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