ORAL PHARMACEUTICAL FORMULATIONS OF VLA-4 ANTAGONISTS

Title:

ORAL PHARMACEUTICAL FORMULATIONS OF VLA-4 ANTAGONISTS

Document Type and Number:

WIPO Patent Application WO/2010/008719

Kind Code:

A3

Abstract:

The present invention provides oral pharmaceutical formulations comprising a VLA-4 antagonist and a surfactant. In one preferred embodiment, the VLA-4 antagonist is the mono-sodium salt of (3S)-3-[({[1-(2-chlorobenzyl)-4-hydroxy-5-methyl-2-oxo-1,2-dihydropyridin-3-yl]amino}carbonyl)amino]-3-(4-methylphenyl)propanoic acid. The present invention also provides methods for treating and/or preventing and/or inhibiting progress of an inflammatory disease using such pharmaceutical formulations.

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Inventors:

HARRIS DAVID (US)
KUMBALE RAMYA (US)

Application Number:

PCT/US2009/047353

Publication Date:

March 11, 2010

Filing Date:

June 15, 2009

Export Citation:

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Assignee:

SCHERING CORP (US)
HARRIS DAVID (US)
KUMBALE RAMYA (US)

International Classes:

A61K9/48; A61K9/16; A61K31/4412

Domestic Patent References:

WO2004044046A2

2004-05-27

Foreign References:

US20050003001A1	2005-01-06
US6238695B1	2001-05-29
FR2761266A1	1998-10-02

Attorney, Agent or Firm:

BALDWIN, Geraldine, Frances (Patent Department K-6-1 19902000 Galloping Hill Roa, Kenilworth New Jersey, US)

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