Title:
ORAL PREPARATION FOR PROMOTING EXPRESSION OF TGF-β, ORAL PREPARATION FOR INHIBITING PRODUCTION OF PAIN-MEDIATING SUBSTANCE, AND ORAL PREPARATION FOR PREVENTING EDEMA
Document Type and Number:
WIPO Patent Application WO/2013/129577
Kind Code:
A1
Abstract:
An oral preparation for promoting the expression of TGF-β comprises hyaluronic acid or a pharmaceutically acceptable salt thereof as an active ingredient, and can promote the expression of TGF-β in plasma. An oral preparation for inhibiting the production of a pain-mediating substance comprises hyaluronic acid or a pharmaceutically acceptable salt thereof as an active ingredient, and can promote the expression of TGF-β in plasma to thereby inhibit the production of the pain-mediating substance. An oral preparation for inhibiting the production of a pain-mediating substance comprises hyaluronic acid or a pharmaceutically acceptable salt thereof as an active ingredient, and can inhibit the production of PGE2 and/or bradykinin which is a pain-mediating substance. An oral preparation for preventing edema comprises hyaluronic acid or a pharmaceutically acceptable salt thereof as an active ingredient, and can inhibit the production of PGE2 and/or bradykinin which is a pain-mediating substance.
Inventors:
KURIHARA HITOSHI (JP)
TSURUKI TAKAHIRO (JP)
ASARI AKIRA (JP)
TSURUKI TAKAHIRO (JP)
ASARI AKIRA (JP)
Application Number:
PCT/JP2013/055431
Publication Date:
September 06, 2013
Filing Date:
February 28, 2013
Export Citation:
Assignee:
KEWPIE CORP (JP)
International Classes:
A61K31/728; A61P7/10; A61P29/00; A61P43/00
Domestic Patent References:
| WO2009113512A1 | 2009-09-17 |
Foreign References:
| JP2009102278A | 2009-05-14 | |||
| JP2001231503A | 2001-08-28 | |||
| JP2002145800A | 2002-05-22 | |||
| JP2009051849A | 2009-03-12 | |||
| JPH06107550A | 1994-04-19 | |||
| JP2002519381A | 2002-07-02 | |||
| JP2001522361A | 2001-11-13 | |||
| JP2011037853A | 2011-02-24 |
Other References:
HAJIME YAMAMOTO ET AL.: "Effect of dietary hyaluronic acid (extracellular matrix: ECM E) on analgesic activity and on the healing of experimental open wound in rat", MEDICINE AND BIOLOGY, vol. 139, no. 6, 1999, pages 253 - 258, XP003022242
BUCHSEL,P.C. ET AL.: "Polyvinylpyrrolidone- sodium hyaluronate gel (Gelclair@): a bioadherent oral gel for the treatment of oral mucositis and other painful oral lesions", EXPERT OPIN. DRUG METAB. TOXICOL., vol. 4, no. 11, 2008, pages 1449 - 54
THE MERCK MANUAL, 1999, pages 253 - 259, 305 TO 318, 1153 TO 1155
CARMONA,J.U. ET AL.: "Effect of the administration of an oral hyaluronan formulation on clinical and biochemical parameters in young horses with osteochondrosis", VET. COMP. ORTHOP. TRAUMATOL., vol. 22, no. 6, 2009, pages 455 - 9
AL-BAYATY, F. ET AL.: "Evaluation of hyaluronate anti-ulcer activity against gastric mucosal injury", AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 5, no. 1, 2011, pages 23 - 30
JENTSCH,H. ET AL.: "Treatment of gingivitis with hyaluronan", JOURNAL OF CLINICAL PERIODONTOLOGY, vol. 30, no. 2, 2003, pages 159 - 64, XP055035278, DOI: doi:10.1034/j.1600-051X.2003.300203.x
ASLAN.F.Y. ET AL.: "Early results of the neural and antioedema therapy at the knee pain [Diz a risinin giderilmesinde noral terapi ile birlikte anti odem tedavinin etkinli i ve erken sonuclari]", TURKIYE FIZIKSEL TIP VE REHABILITASYON DERGISI, vol. 57, no. SUPP.1, 2011, pages 158
BUCHSEL,P.C. ET AL.: "Polyvinylpyrrolidone- sodium hyaluronate gel (Gelclair@): a bioadherent oral gel for the treatment of oral mucositis and other painful oral lesions", EXPERT OPIN. DRUG METAB. TOXICOL., vol. 4, no. 11, 2008, pages 1449 - 54
THE MERCK MANUAL, 1999, pages 253 - 259, 305 TO 318, 1153 TO 1155
CARMONA,J.U. ET AL.: "Effect of the administration of an oral hyaluronan formulation on clinical and biochemical parameters in young horses with osteochondrosis", VET. COMP. ORTHOP. TRAUMATOL., vol. 22, no. 6, 2009, pages 455 - 9
AL-BAYATY, F. ET AL.: "Evaluation of hyaluronate anti-ulcer activity against gastric mucosal injury", AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY, vol. 5, no. 1, 2011, pages 23 - 30
JENTSCH,H. ET AL.: "Treatment of gingivitis with hyaluronan", JOURNAL OF CLINICAL PERIODONTOLOGY, vol. 30, no. 2, 2003, pages 159 - 64, XP055035278, DOI: doi:10.1034/j.1600-051X.2003.300203.x
ASLAN.F.Y. ET AL.: "Early results of the neural and antioedema therapy at the knee pain [Diz a risinin giderilmesinde noral terapi ile birlikte anti odem tedavinin etkinli i ve erken sonuclari]", TURKIYE FIZIKSEL TIP VE REHABILITASYON DERGISI, vol. 57, no. SUPP.1, 2011, pages 158
Attorney, Agent or Firm:
HARUKA PATENT & TRADEMARK ATTORNEYS (JP)
Patent business corporation far international patent firm (JP)
Patent business corporation far international patent firm (JP)
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