Title:
ORALLY ADMINISTERED ADSORBENT, THERAPEUTIC AGENT FOR RENAL DISEASE, AND THERAPEUTIC AGENT FOR LIVER DISEASE
Document Type and Number:
WIPO Patent Application WO/2014/129614
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide an orally administered adsorbent capable of adsorbing large quantities of tryptophan or indoxyl sulfate in the presence of bile acid. Accordingly, an orally administered adsorbent is characterized by including spherical active carbon which has: a bulk density of 0.30-0.46 g/mL; a specific surface area obtained using the Brunauer-Emmett-Teller (BET) method of at least 2000 m2/g; a total acid group content of less than 0.30 meq/g; a volume of pores having diameters in the range 20-10000 nm of not more than 0.21 mL/g; and a micropore volume ratio (Vm) of at least 1.0, said micropore volume ratio (Vm) being obtained using formula (1), namely Vm = (V2.0-V1.1)/(V1.1-V0.64) (in formula (1), V2.0, V1.1, and V0.64 are the cumulative volumes of pores having diameters of not more than 2.0 nm, not more than 1.1 nm, and not more than 0.64 nm, respectively, said volumes being calculated from nitrogen adsorption amounts using the Saito-Foley (SF) method).
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Inventors:
SONOBE NAOHIRO (JP)
WAKAHOI TAKASHI (JP)
AKITA TAKAHIRO (JP)
WAKAHOI TAKASHI (JP)
AKITA TAKAHIRO (JP)
Application Number:
PCT/JP2014/054261
Publication Date:
August 28, 2014
Filing Date:
February 24, 2014
Export Citation:
Assignee:
KUREHA CORP (JP)
International Classes:
A61P1/16; A61K33/44; A61P13/12; A61P39/02; B01J20/20; C01B32/336
Domestic Patent References:
| WO2005094844A1 | 2005-10-13 | |||
| WO2010001485A1 | 2010-01-07 | |||
| WO2008152994A1 | 2008-12-18 |
Foreign References:
| JP2012102072A | 2012-05-31 | |||
| JPS6211611B2 | 1987-03-13 | |||
| JP2006131461A | 2006-05-25 | |||
| JP2006015334A | 2006-01-19 | |||
| JP2011037749A | 2011-02-24 |
Other References:
JAPANESE JOURNAL OF NEPHROLOGY, vol. 32, no. 6, 1990, pages 65 - 71
JAPANESE JOURNAL OF CLINICAL DIALYSIS, vol. 14, no. 4, 1998, pages 433 - 438
SAITO, A.; FOLEY, H.C., ACHE JOURNAL, vol. 37, no. 3, 1991, pages 429
HORVATH, G.; KAWAZOE, K., J. CHEM. ENG. JAPAN, vol. 16, no. 6, 1983, pages 470
SAITO, A.; FOLEY, H.C., ALCHE JOURNAL, vol. 37, no. 3, 1991, pages 429
N. HONDA; K. KOISO; K. KUROGAWA: "Clinical Nephrology", 1990, ASAKURA PUBLISHING
"Nephrology", 1981, IGAKU SHOIN
JAPANESE JOURNAL OF CLINICAL DIALYSIS, vol. 14, no. 4, 1998, pages 433 - 438
SAITO, A.; FOLEY, H.C., ACHE JOURNAL, vol. 37, no. 3, 1991, pages 429
HORVATH, G.; KAWAZOE, K., J. CHEM. ENG. JAPAN, vol. 16, no. 6, 1983, pages 470
SAITO, A.; FOLEY, H.C., ALCHE JOURNAL, vol. 37, no. 3, 1991, pages 429
N. HONDA; K. KOISO; K. KUROGAWA: "Clinical Nephrology", 1990, ASAKURA PUBLISHING
"Nephrology", 1981, IGAKU SHOIN
Attorney, Agent or Firm:
MORITA Kenichi et al. (JP)
Ken-ichi Morita (JP)
Ken-ichi Morita (JP)
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