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Title:
ORALLY AVAILABLE SPHINGOSINE 1-PHOSPHATE RECEPTOR AGONISTS AND ANTAGONISTS
Document Type and Number:
WIPO Patent Application WO2005041899
Kind Code:
A3
Abstract:
The present invention relates to S1P analogs that have activity as S1Preceptor modulating agents and the use of such compounds to treat diseases associated with inappropriate S1P receptor activity. The compounds have the general structure (I) wherein R11 is C5-C18 alkyl or C5-C18 alkenyl; Q is selected from the group consisting of C3-C6 optionally substituted cycloalkyl, C3-C6 optionally substituted heterocyclic, C3-C6 optionally substituted aryl C3-C6 optionally substituted heteroaryl and; R2 is selected from the group consisting of H, C1-C4 alkyl, (C1-C4 alkyl)OH and (C1-C4 alkyl)NH2; R23 is H or C1-C4 alkyl, and R15 is a phosphonate ester or a phosphate ester or a pharmaceutically acceptable salt or tautomer thereof.

Inventors:
LYNCH KEVIN R (US)
MACDONALD TIMOTHY L (US)
Application Number:
US2004036563W
Publication Date:
November 02, 2006
Filing Date:
November 03, 2004
Export Citation:
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Assignee:
UNIVERSITY OF VIRGINIA PATENT FOUNDATION
LYNCH, KEVIN, R.
MACDONALD, TIMOTHY, L.
International Classes:
A61K31/4164; A61K31/4196; A61K31/426; A61K31/433; C07D231/10; C07D233/61; C07D263/48; C07D273/02; C07D277/28; C07D295/18; C07D307/38; C07F9/6506; A61K
Domestic Patent References:
WO2006020951A12006-02-23
WO2004010949A22004-02-05
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