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Title:
ORBIT AZINE-FUMARATE, HYDRATE, CRYSTAL FORM AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2017/015784
Kind Code:
A1
Abstract:
The present invention belongs to the field of pharmaceutical chemistry, and particularly relates to an orbit azine-fumarate, a hydrate, a crystal form and a preparation method therefor. Specifically, in the present invention, different crystal forms of orbit azine-fumarate, orbit azine-fumarate hydrates and crystal forms thereof and an amorphous form of orbit azine-fumarate are prepared by adjusting the formulation ratio of orbit azine and fumaric acid and adopting different crystallization methods. The present invention provides the possibility of providing an orbit azine-fumarate having a better pharmaceutical effect, being easier to prepare and having a better storage stability.

Inventors:
CHENG LIREN (CN)
Application Number:
PCT/CN2015/085025
Publication Date:
February 02, 2017
Filing Date:
July 24, 2015
Export Citation:
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Assignee:
SHENZHEN INST OF XIANGYA BIOMEDICINE (CN)
International Classes:
C07D243/08; A61K31/551; A61P35/00
Domestic Patent References:
WO2006128173A22006-11-30
Foreign References:
CN101503394A2009-08-12
CN101987835A2011-03-23
CN101941953A2011-01-12
CN102276556A2011-12-14
Other References:
TANG, JING ET AL.: "Absorption Mechanism of SM-1: A Procaspase-3-Activaed Anti-Tumour Agent", CHINESE PHARMACOLOGICAL BULLETIN, vol. 30, no. 4, 21 March 2014 (2014-03-21), pages 542 - 546, XP009504712
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
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