Title:
ORBIT AZINE-FUMARATE, HYDRATE, CRYSTAL FORM AND PREPARATION METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2017/015784
Kind Code:
A1
Abstract:
The present invention belongs to the field of pharmaceutical chemistry, and particularly relates to an orbit azine-fumarate, a hydrate, a crystal form and a preparation method therefor. Specifically, in the present invention, different crystal forms of orbit azine-fumarate, orbit azine-fumarate hydrates and crystal forms thereof and an amorphous form of orbit azine-fumarate are prepared by adjusting the formulation ratio of orbit azine and fumaric acid and adopting different crystallization methods. The present invention provides the possibility of providing an orbit azine-fumarate having a better pharmaceutical effect, being easier to prepare and having a better storage stability.
More Like This:
Inventors:
CHENG LIREN (CN)
Application Number:
PCT/CN2015/085025
Publication Date:
February 02, 2017
Filing Date:
July 24, 2015
Export Citation:
Assignee:
SHENZHEN INST OF XIANGYA BIOMEDICINE (CN)
International Classes:
C07D243/08; A61K31/551; A61P35/00
Domestic Patent References:
WO2006128173A2 | 2006-11-30 |
Foreign References:
CN101503394A | 2009-08-12 | |||
CN101987835A | 2011-03-23 | |||
CN101941953A | 2011-01-12 | |||
CN102276556A | 2011-12-14 |
Other References:
TANG, JING ET AL.: "Absorption Mechanism of SM-1: A Procaspase-3-Activaed Anti-Tumour Agent", CHINESE PHARMACOLOGICAL BULLETIN, vol. 30, no. 4, 21 March 2014 (2014-03-21), pages 542 - 546, XP009504712
Attorney, Agent or Firm:
CCPIT PATENT AND TRADEMARK LAW OFFICE (CN)
Download PDF:
Previous Patent: HUMANIZED ANTI-CD19 ANTIBODY AND USE THEREOF
Next Patent: METHOD FOR USER EQUIPMENT TO SEND SIGNAL, AND USER EQUIPMENT
Next Patent: METHOD FOR USER EQUIPMENT TO SEND SIGNAL, AND USER EQUIPMENT