Title:
ORGANIC COMPOUND ANALYZER, ORGANIC COMPOUND ANALYSIS METHOD, AND PROGRAM FOR ORGANIC COMPOUND ANALYZER
Document Type and Number:
WIPO Patent Application WO/2018/034205
Kind Code:
A1
Abstract:
To provide an organic compound analyzer capable of accurately identifying change feature points in which are reflected microscopic structural changes of an organic compound. The present invention is provided with: a measured data storage unit 2 for storing measured data pairing spectrums, measured with a plurality of differing external stimulation conditions regarding a sample comprising the organic compound, with the external stimulation conditions used to measure each of the spectrums; an evaluation reference vector setting unit 3 for setting loading indicating the weighting with respect to each wave number at which the spectrums were measured; a score calculation unit 4 for calculating a score, on the basis of the loading and the measured data, corresponding to the loading for each external stimulation condition used to measure the spectrums; and a change feature point identification unit 5 for calculating the denaturation temperature of the organic compound on the basis of changes in the score with respect to the external stimulation conditions.
Inventors:
OTA CHIKASHI (JP)
Application Number:
PCT/JP2017/028757
Publication Date:
February 22, 2018
Filing Date:
August 08, 2017
Export Citation:
Assignee:
HORIBA LTD (JP)
International Classes:
G01N21/65; G01N33/483
Foreign References:
| JP2011174906A | 2011-09-08 | |||
| JPS5649825B2 | 1981-11-25 |
Other References:
BO YUAN: "Temperature-Dependent Near-Infrared Spectra of Bovine Serum Albumin in Aqueous Solutions: Spectral Analysis by Principal Component Analysis and Evolving Factor Analysis", APPLIED SPECTROSCOPY, vol. 57, no. 10, 2003, pages 1223 - 1229, XP055578180
AKIFUMI UDA: "Principal Component Analysis for Quality Control", PDA JOURNAL OF GMP AND VALIDATION IN JAPAN, vol. 8, no. 2, 2006, pages 94 - 105, XP009515596, DOI: 10.11347/pda.8.94
CHIKASHI OTA ET AL.: "Assessment of the Protein-Protein Interactions in a Highly Concentrated Antibody Solution by Using Raman Spectroscopy", PHARMACEUTICAL RESEARCH, vol. 33, no. 4, December 2015 (2015-12-01), pages 956 - 969, XP035927679, doi:10.1007/s11095-015-1842-8
AKIFUMI UDA: "Principal Component Analysis for Quality Control", PDA JOURNAL OF GMP AND VALIDATION IN JAPAN, vol. 8, no. 2, 2006, pages 94 - 105, XP009515596, DOI: 10.11347/pda.8.94
CHIKASHI OTA ET AL.: "Assessment of the Protein-Protein Interactions in a Highly Concentrated Antibody Solution by Using Raman Spectroscopy", PHARMACEUTICAL RESEARCH, vol. 33, no. 4, December 2015 (2015-12-01), pages 956 - 969, XP035927679, doi:10.1007/s11095-015-1842-8
Attorney, Agent or Firm:
NISHIMURA, Ryuhei (JP)
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