Title:
ORGANIC COMPOUNDS
Document Type and Number:
WIPO Patent Application WO2005051895
Kind Code:
A8
Abstract:
Disclosed are d-amino-?-hydroxy-?-aryl-alkanoic acid amide compounds of formula (I) and the salts thereof, having renin-inhibiting properties. Also disclosed are pharmaceutical compositions comprising these compounds and methods of administering them for the treatment of hypertension, atherosclerosis, unstable coronary syndrome, congestive heart failure, cardiac hypertrophy, cardiac fibrosis, cardiomyopathy postinfarction, unstable coronary syndrome, diastolic dysfunction, chronic kidney disease, hepatic fibrosis, complications resulting from diabetes, such as nephropathy, vasculopathy and neuropathy, diseases of the coronary vessels, restenosis following angioplasty, raised intra-ocular pressure, glaucoma, abnormal vascular growth, hyperaldosteronism, cognitive impairment, alzheimers, dementia, anxiety states and cognitive disorders.
Inventors:
BAESCHLIN DANIEL KASPAR (CH)
MAIBAUM JUERGEN KLAUS (DE)
SELLNER HOLGER (CH)
MAIBAUM JUERGEN KLAUS (DE)
SELLNER HOLGER (CH)
Application Number:
PCT/EP2004/013412
Publication Date:
July 20, 2006
Filing Date:
November 25, 2004
Export Citation:
Assignee:
NOVARTIS AG (CH)
NOVARTIS PHARMA GMBH (AT)
BAESCHLIN DANIEL KASPAR (CH)
MAIBAUM JUERGEN KLAUS (DE)
SELLNER HOLGER (CH)
NOVARTIS PHARMA GMBH (AT)
BAESCHLIN DANIEL KASPAR (CH)
MAIBAUM JUERGEN KLAUS (DE)
SELLNER HOLGER (CH)
International Classes:
A61K31/165; A61K31/275; A61K31/325; A61K31/343; A61K31/357; A61K31/381; A61K31/402; A61K31/44; A61K31/5377; C07C237/20; C07C237/24; C07C255/50; C07C255/60; C07C271/22; C07C271/24; C07C323/29; C07C323/41; C07D207/09; C07D295/027; C07D307/79; C07D313/08; C07D319/18; C07D333/08; C07D295/02
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