Title:
ORGANIC NANOTUBE HAVING HYDROPHOBIZED INNER SURFACE, AND ENCAPSULATED MEDICINAL AGENT PREPARED USING THE NANOTUBE
Document Type and Number:
WIPO Patent Application WO/2012/153576
Kind Code:
A1
Abstract:
Provided is an organic nanotube having a hydrophobized inner surface, which has a hydrophilized outer surface and a hydrophobized hollow cylinder inner surface, comprises an asymmetric bicipital lipid molecule represented by general formula (1) and a derivative thereof represented by general formula (2), and is formed by binary self-assembly. In formulae (1) and (2), the same symbols have the same meanings, wherein G represents a 1-glucopyranosyl group or a 2-glucopyranosyl group; and n represents an integer of 12-22. Particularly, an asymmetric bicipital lipid molecule and an ester thereof respectively represented by general formulae (1) and (2) wherein n = an integer of 18-22, Z1 = Z2 = a single chain, Y = Gly, m's = independently an integer of 3-6, X = OH, and R = a methoxy group, an ethoxy group, or a benzyloxy group are novel substances, and can form a carboxylic-acid-type asymmetric nanotube alone or a binary system thereof can also form the carboxylic-acid-type asymmetric nanotube by binary self assembly.
Inventors:
KAMETA NAOHIRO (JP)
DING WUXIAO (JP)
MASUDA MITSUTOSHI (JP)
MINAMIKAWA HIROYUKI (JP)
WADA MOMOYO (JP)
SHIMIZU TOSHIMI (JP)
DING WUXIAO (JP)
MASUDA MITSUTOSHI (JP)
MINAMIKAWA HIROYUKI (JP)
WADA MOMOYO (JP)
SHIMIZU TOSHIMI (JP)
Application Number:
PCT/JP2012/058724
Publication Date:
November 15, 2012
Filing Date:
March 30, 2012
Export Citation:
Assignee:
NAT INST OF ADVANCED IND SCIEN (JP)
KAMETA NAOHIRO (JP)
DING WUXIAO (JP)
MASUDA MITSUTOSHI (JP)
MINAMIKAWA HIROYUKI (JP)
WADA MOMOYO (JP)
SHIMIZU TOSHIMI (JP)
KAMETA NAOHIRO (JP)
DING WUXIAO (JP)
MASUDA MITSUTOSHI (JP)
MINAMIKAWA HIROYUKI (JP)
WADA MOMOYO (JP)
SHIMIZU TOSHIMI (JP)
International Classes:
B82B1/00; A61K9/51; A61K9/62; A61K38/00; A61K38/16; A61K47/42; B82Y5/00; B82Y40/00
Domestic Patent References:
| WO2006090821A1 | 2006-08-31 |
Foreign References:
| JP2002322190A | 2002-11-08 | |||
| JP2011184391A | 2011-09-22 | |||
| JP2012051828A | 2012-03-15 |
Other References:
TOSHIMI SHIMIZU: "Molecular Building Blocks That Self-Assemble into Discrete Organic Tubular Architectures", JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY, vol. 66, no. 3, 1 March 2008 (2008-03-01), JAPAN, pages 229 - 238
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Claims: