Title:
ORGANIC NITROXIDE RADICAL COMPOUND AND METHOD FOR PRODUCING SAME, AND NANO EMULSION PARTICLES AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/154767
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide: nano emulsion particles which can be used as a metal-free contrast agent for MRI or the like; and an organic nitroxide radical compound which makes it possible to easily prepare the nano emulsion particles.
An organic nitroxide radical compound represented by formula (1) (wherein R1 represents a linear alkyl group having 10 to 26 carbon atoms); and nano emulsion particles each of which is composed of the organic nitroxide radical compound and a nonionic surfactant at a molar ratio of 0.8:1 to 1.2:1 and each of which has a nitroxide radical enclosed therein.
Inventors:
TAMURA RUI (JP)
NAGURA KOTA (JP)
NAGURA KOTA (JP)
Application Number:
PCT/JP2017/008469
Publication Date:
September 14, 2017
Filing Date:
March 03, 2017
Export Citation:
Assignee:
UNIV KYOTO (JP)
International Classes:
C07D207/46; A61K9/107; A61K47/34; A61K49/20
Domestic Patent References:
| WO2009133647A1 | 2009-11-05 |
Foreign References:
| JP2012188388A | 2012-10-04 | |||
| JP2009215182A | 2009-09-24 | |||
| US4099918A | 1978-07-11 |
Other References:
SHOBHA,J.: "Diffrential Modes of Incorporation of Probe Molecules in Micelles and in Bilayer Vesicles", THE JOURNAL OF PHYSICAL CHEMISTRY, vol. 93, no. 1, 1989, pages 17 - 20, XP055414125
YOSHITOMI,T.: "Design of Core-Shell-Type Nanoparticles Carrying Stable Radicals in the Core", BIOMACROMOLECULES, vol. 10, no. 3, 9 March 2009 (2009-03-09), pages 596 - 601, XP055414127
YOSHITOMI,T.: "Design of Core-Shell-Type Nanoparticles Carrying Stable Radicals in the Core", BIOMACROMOLECULES, vol. 10, no. 3, 9 March 2009 (2009-03-09), pages 596 - 601, XP055414127
Attorney, Agent or Firm:
SAEGUSA & PARTNERS (JP)
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