Title:
ORGANISM AND SUBSTANCE MANUFACTURING METHOD
Document Type and Number:
WIPO Patent Application WO/2016/063516
Kind Code:
A1
Abstract:
Provided is an organism and substance manufacturing method that enables appropriate control of organism proliferation and substance production. The organism has equipped in DNA: a proliferation participating region that relates to organism proliferation; a first promoter region that expresses the proliferation participating region under the condition of bonding with a first compound; a substance production participating region that participates in substance production; a second promoter region that expresses the substance production participating region under the condition of bonding with a second compound; a CcaS gene region; a CcaR gene region; a RcaE gene region; a RcaF gene region; and a RcaC gene region, wherein one of the first compound and the second compound is phosphorylated CcaR generated from exposure to green light, and the other is phosphorylated RcaC generated from exposure to red light.
Inventors:
FUKUDA HIROAKI (JP)
IKEUCHI MASAHIKO (JP)
NAGAKUBO MASAO (JP)
HIROSE YUU (JP)
IKEUCHI MASAHIKO (JP)
NAGAKUBO MASAO (JP)
HIROSE YUU (JP)
Application Number:
PCT/JP2015/005259
Publication Date:
April 28, 2016
Filing Date:
October 19, 2015
Export Citation:
Assignee:
DENSO CORP (JP)
UNIV TOKYO (JP)
NAT UNIV CORP TOYOHASHI UNIV (JP)
UNIV TOKYO (JP)
NAT UNIV CORP TOYOHASHI UNIV (JP)
International Classes:
C12N1/21; C12N15/09; C12P5/00; C12P7/24; C12P7/40; C12P13/04; C12P19/02; C12P19/04
Domestic Patent References:
| WO2008067089A2 | 2008-06-05 |
Other References:
REI NARIKAWA ET AL.: "Light regulation of extracellular polysaccaride production by developing various photo-switches", ABSTRACTS OF THE 64TH ANNUAL MEETING OF THE SOCIETY FOR BIOTECHNOLOGY, 2012, Japan, pages 130
TABOR JEFFREY J. ET AL.: "Multichromatic control of gene expression in Escherichia coli", JOURNAL OF MOLECULAR BIOLOGY, vol. 405, no. 2, 2011, pages 315 - 324, XP027583590
HIROSE YUU ET AL.: "Cyanobacteriochrome CcaS is the green light receptor that induces the expression of phycobilisome linker protein", PNAS, vol. 105, no. 28, 2008, pages 9528 - 9533, XP055275024
CAMERON D. EWEN ET AL.: "A brief history of synthetic biology", NATURE REVIEWS MICROBIOLOGY, vol. 12, no. 5, May 2014 (2014-05-01), pages 381 - 390, XP055275027
ABE KOICHI ET AL.: "Engineering of a green-light inducible gene expression system in Synechocystis sp. PCC6803", MICROBIAL BIOTECHNOLOGY, vol. 7, no. 2, March 2014 (2014-03-01), pages 177 - 183, XP055275029
TABOR JEFFREY J. ET AL.: "Multichromatic control of gene expression in Escherichia coli", JOURNAL OF MOLECULAR BIOLOGY, vol. 405, no. 2, 2011, pages 315 - 324, XP027583590
HIROSE YUU ET AL.: "Cyanobacteriochrome CcaS is the green light receptor that induces the expression of phycobilisome linker protein", PNAS, vol. 105, no. 28, 2008, pages 9528 - 9533, XP055275024
CAMERON D. EWEN ET AL.: "A brief history of synthetic biology", NATURE REVIEWS MICROBIOLOGY, vol. 12, no. 5, May 2014 (2014-05-01), pages 381 - 390, XP055275027
ABE KOICHI ET AL.: "Engineering of a green-light inducible gene expression system in Synechocystis sp. PCC6803", MICROBIAL BIOTECHNOLOGY, vol. 7, no. 2, March 2014 (2014-03-01), pages 177 - 183, XP055275029
Attorney, Agent or Firm:
KIN, Junhi (JP)
Gold Junki (JP)
Gold Junki (JP)
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