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Title:
ORGANOID AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2018/047914
Kind Code:
A1
Abstract:
An organoid characterized by having a metastatic tendency when transplanted into an immunocompetent non-human animal of the same species. A cell strain characterized by having a metastatic tendency when transplanted into an immunocompetent non-human animal of the same species. A non-human animal characterized by carrying the organoid or the cell strain.

Inventors:
OSHIMA Masanobu (Nu7 Kakuma-machi, Kanazawa-sh, Ishikawa 92, 〒9201192, JP)
NAKAYAMA Mizuho (Nu7 Kakuma-machi, Kanazawa-sh, Ishikawa 92, 〒9201192, JP)
SAKAI Eri (Nu7 Kakuma-machi, Kanazawa-sh, Ishikawa 92, 〒9201192, JP)
Application Number:
JP2017/032335
Publication Date:
March 15, 2018
Filing Date:
September 07, 2017
Export Citation:
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Assignee:
NATIONAL UNIVERSITY CORPORATION KANAZAWA UNIVERSITY (Nu7 Kakuma-machi, Kanazawa-shi Ishikawa, 92, 〒9201192, JP)
International Classes:
C12N5/09; A01K67/027; C12Q1/02; G01N33/15; G01N33/50
Domestic Patent References:
WO2015196012A12015-12-23
Other References:
WEEBER F. ET AL.: "Preserved genetic diversity in organoids cultured from biopsies of human colorectal cancer metastases", PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, vol. 112, no. 43, 2015, pages 13308 - 13311, XP055497441
BOJ S.F. ET AL.: "Organoid Models of Human and Mouse Ductal Pancreatic Cancer", CELL, vol. 160, no. 1-2, 2015, pages 324 - 338, XP055484794
CAO D. ET AL.: "A New Tumorsphere Culture Condition Restores Potentials of Self-Renewal and Metastasis of Primary Neuroblastoma in a Mouse Neuroblastoma Model", PLOS ONE, vol. 9, no. 1, 2014, pages 1 - 8, XP055403773
OOSHIMA, HIROKO ET AL.: "Carcinogenesis caused by genetic mutation and interaction of microenvironment. Experimental Medicine", JAPANESE JOURNAL OF CIRCULATION RESEARCH, vol. 34, no. 14, 1 September 2016 (2016-09-01), pages 2294 - 2299
MATANO M. ET AL.: "Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids", NATURE MEDICINE, vol. 21, no. 3, 2015, pages 256 - 262, XP055429513
FUJII M ET AL.: "A Colorectal Tumor Organoid Library Demonstrates Progressive Loss of Niche Factor Requirements during Tumorigenesis", CELL STEM CELL, vol. 18, no. 6, 2 June 2016 (2016-06-02), pages 827 - 838, XP029567586
O'ROURKE K.P. ET AL.: "Transplantation of engineered organoids enables rapid generation of metastatic mouse models of colorectal cancer", NATURE BIOTECHNOLOGY, vol. 35, no. 6, 1 May 2017 (2017-05-01), pages 577 - 582, XP055497444
Attorney, Agent or Firm:
TANAI Sumio et al. (1-9-2, Marunouchi Chiyoda-k, Tokyo 20, 〒1006620, JP)
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