ORGANOMIMETIC DEVICES AND METHODS OF USE AND MANUFACTURING THEREOF

Title:

ORGANOMIMETIC DEVICES AND METHODS OF USE AND MANUFACTURING THEREOF

Document Type and Number:

WIPO Patent Application WO/2015/138032

Kind Code:

A3

Abstract:

An organomimetic device includes a microfluidic device that can be used to culture cells in its microfluidic channels. The organomimetic device can be part of dynamic system that can apply mechanical forces to the cells by modulating the microfluidic device and the flow of fluid through the microfluidic channels. The membrane in the organomimetic device can be modulated mechanically via pneumatic means and/or mechanical means. The organomimetic device can be manufactured by the fabrication of individual components separately, for example, as individual layers that can be subsequently laminated together.

Inventors:

FERNANDEZ-ALCON JOSE (US)
WEN NORMAN (US)
NOVAK RICHARD (US)
INGBER DONALD E (US)
HAMILTON GERALDINE A (US)
HINOJOSA CHRISTOPHER (US)
DOMANSKY KAREL (US)
LEVNER DANIEL (US)
THOMPSON II GUY (US)
HAJIPOURAN BENAM KAMBEZ (US)
VILLENAVE REMI (US)
UMUNDUM THOMAS (AT)
PARIS ALFRED (AT)
BAUER GEORG (AT)

Application Number:

PCT/US2014/071570

Publication Date:

December 03, 2015

Filing Date:

December 19, 2014

Export Citation:

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Assignee:

HARVARD COLLEGE (US)
FERNANDEZ-ALCON JOSE (US)
WEN NORMAN (US)
NOVAK RICHARD (US)

International Classes:

B01L3/00; C12M3/00

Domestic Patent References:

WO2012118799A2	2012-09-07
WO2013086486A1	2013-06-13
WO2013085909A1	2013-06-13

Foreign References:

US20110250585A1	2011-10-13
US20020166585A1	2002-11-14

Other References: