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Title:
OSPC-BASED DIAGNOSTIC TEST FOR LYME DISEASE
Document Type and Number:
WIPO Patent Application WO/2010/132758
Kind Code:
A3
Abstract:
The present invention relates, e.g., to a composition comprising OspC polypeptides from Lyme Disease-causing Borrelia species, wherein the composition comprises one or more isolated polypeptides from OspC families as follows: (a) at least one of each of K, B, and J; or (b) at least one of each of K and E; or (c) at least one of each of K and F. These polypeptides bind specifically to antibodies induced by a causative agent of Lyme disease (a pathogenic Borrelia), e.g. in a sample from a subject having Lyme disease, and exhibit a high degree of cross-reactivity with OscC polypeptides from other families. Therefore, the noted combinations of polypeptides can be used to diagnose infection from broad cross-section of Borrelia. Also disclosed are diagnostic reagents and kits comprising compositions of the invention, methods for diagnosing infection by Borrelia, and vaccines against Borrelia infection.

Inventors:
GOMES-SOLECKI, Maria, J. (UTHSC, Molecular Sciences Suite 301C,858 Madison Avenu, Memphis TN, 38163, US)
DATTWYLER, Raymond, J. (Biopeptides Corp, 18 Woodhull Roa, East Setauket NY, 11733, US)
Application Number:
US2010/034885
Publication Date:
April 07, 2011
Filing Date:
May 14, 2010
Export Citation:
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Assignee:
GOMES-SOLECKI, Maria, J. (UTHSC, Molecular Sciences Suite 301C,858 Madison Avenu, Memphis TN, 38163, US)
DATTWYLER, Raymond, J. (Biopeptides Corp, 18 Woodhull Roa, East Setauket NY, 11733, US)
International Classes:
G01N33/68; A61K39/02; A61P31/04; C07K14/195; G01N33/569
Domestic Patent References:
WO2007065098A22007-06-07
Foreign References:
US7060281B12006-06-13
US20030059894A12003-03-27
US20030138866A12003-07-24
Other References:
CHRISTOPHER, G. ET AL.: "Development of an OspC-based tetravalent, recombinan t, chimeric vaccinogen that elicits bactericidal antibody against diverse Ly me disease spirochete strains", VACCINE, vol. 25, 2007, pages 466 - 480, XP005798900, DOI: doi:10.1016/j.vaccine.2006.07.052
Attorney, Agent or Firm:
HOBBS, Ann S. et al. (VENABLE LLP, P.O. Box 34385Washington, DC, 20043-9998, US)
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