Title:
OSTEOCALCIN AS A TREATMENT FOR COGNITIVE DISORDERS
Document Type and Number:
WIPO Patent Application WO/2014/152497
Kind Code:
A3
Abstract:
Methods and compositions for treating or preventing cognitive disorders in mammals, preferably humans, are provided. The methods generally involve modulation of the OST-PTP signaling pathway or the PTP-1B signaling pathway involving gamma-carboxylase and osteocalcin, e.g., by administratin of undercarboxylated/uncarboxylated osteocalcin. Disorders amenable to treatment by the methods include, but are not limited to, cognitive loss due to neurodegeneration associated with aging, anxiety, depression, memory loss, learning difficulties, and cognitive disorders associated with food deprivation during pregnancy.
Inventors:
KARSENTY GERARD (US)
OURY FRANCK (US)
OURY FRANCK (US)
Application Number:
PCT/US2014/027404
Publication Date:
November 27, 2014
Filing Date:
March 14, 2014
Export Citation:
Assignee:
UNIV COLUMBIA (US)
International Classes:
A01N33/00; A61K38/00
Foreign References:
| US20100190697A1 | 2010-07-29 |
Other References:
UMEGAKI: "Neurodegeneration in diabetes mellitus.", ADV EXP MED BIOL., vol. 724, 2012, pages 258 - 265
Attorney, Agent or Firm:
SOMERVILLE, Deborah, A. et al. (One BroadwayNew York, NY, US)
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