Title:
OSTEOGENESIS PROMOTER
Document Type and Number:
WIPO Patent Application WO/2012/157237
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide an osteogenesis promoter for directly promoting osteogenesis by osteoblasts, and an agent for preventing and treating bone disease. The present invention is characterized in that a binding inhibitor substance of semaphorin 4D and plexin B1 is used. For the binding inhibitor substance, suitable examples include anti-semaphorin 4D antibody, anti-plexin B1 antibody, and protein comprising the extracellular domain of plexin B1.
Inventors:
TAKAYANAGI HIROSHI (JP)
NEGISHI TAKAKO (JP)
NEGISHI TAKAKO (JP)
Application Number:
PCT/JP2012/003113
Publication Date:
November 22, 2012
Filing Date:
May 11, 2012
Export Citation:
Assignee:
NAT UNIV CORP TOKYO MED & DENT (JP)
TAKAYANAGI HIROSHI (JP)
NEGISHI TAKAKO (JP)
TAKAYANAGI HIROSHI (JP)
NEGISHI TAKAKO (JP)
International Classes:
A61K45/00; A61K38/00; A61K39/395; A61P19/00; A61P19/02; A61P19/08; A61P19/10; A61P29/00; A61P43/00; G01N33/15; G01N33/53; C12N15/09
Foreign References:
| JP2007308465A | 2007-11-29 | |||
| JP2001157583A | 2001-06-12 | |||
| JP2005509629A | 2005-04-14 |
Other References:
ITO Y. ET AL.: "Sema4D/Plexin-Bl activates PTEN via R-Ras GAP activity, inducing growth cone collapse", BULLETIN OF THE JAPANESE SOCIETY FOR NEUROCHEMISTRY, vol. 46, no. 2, 3, 2007, pages 521, XP055136406
MUTSUMI HIROTANI ET AL.: "Semaphorin 4D to sono Juyotai Plexin B1 no Saibonai Joho Dentatsukei no Kaiseki", BULLETIN OF THE JAPANESE SOCIETY FOR NEUROCHEMISTRY, vol. 40, no. 2/3, 2001, pages 269, XP008172113
TAKESHI SATO ET AL.: "Kotsu Saibo ni Okeru semaphoring Signal no Kento", JOURNAL OF THE JAPANESE STOMATOLOGICAL SOCIETY, vol. 60, no. 1, 10 January 2011 (2011-01-10), pages 112, XP008172118
T NEGISI-KOGA ET AL.: "Suppression of bone formation by osteoclastic expression of semaphorin 4D", NATURE MEDICINE, vol. 17, no. 11, November 2011 (2011-11-01), pages 1473 - 1480, XP055136410
See also references of EP 2711023A4
B.J. DICKSON, SCIENCE, vol. 298, 6 December 2002 (2002-12-06), pages 1959
A.B. HUBER; A.L. KOLODKIN; D.D. GINTY; J.F. CLOUTIER, ANNUAL REVIEW NEUROSCIENCE, vol. 26, 2003, pages 509
N. TAKAGAHARA ET AL., NAT. CELL BIOL, vol. 8, June 2006 (2006-06-01), pages 615
N. IRIE ET AL., CELL METAB, vol. 4, August 2006 (2006-08-01), pages 111
C. ZHAO ET AL., CELL METAB, vol. 4, August 2006 (2006-08-01), pages 111
L OINUMA ET AL., SCIENCE, vol. 305, no. 5685, 6 August 2004 (2004-08-06), pages 862 - 865
ISHIDA MASANARI; KANEDA TOSHIO; MUTO AKIHIO; YOSHIDA MASASHI: "Meeting Program Abstracts of the Japan Society of Bone Metabolism", ANALYSIS OF BIOACTION IN BONE METABOLISM IN OSTEOCLAST-DERIVEDSEMAPHORIN 4D, vol. 25, June 2007 (2007-06-01), pages 266
ROMAIN DACQUIN; CHANTAL DOMENGET; PIERRE JURDIC; IRMA MACHUCA-GAYET: "ASBMR 2010 Annual Meeting Abstracts, Presentation Abstracts, Presentation Number MOO 152", PHYSIOLOGICAL CONTROL OF BONE RESORPTION BY SEMAPHORIN 4D IS DEPENDENT ON OVARIAN FUNCTION
TOMIZUKA ET AL., PROC NATI ACAD SCI USA, vol. 97, pages 722
NAT BIOTECHNOL., vol. 14, 1996, pages 845
KELLER; MILLSTEIN, NATURE, vol. 256, 1975, pages 495 - 497
P.J. DELVES: "Antibody Production Essential Techniques", 1997, WILEY
P. SHEPHERD; C. DEAN: "Monoclonal Antibodies", 2000, OXFORD UNIVERSITY PRESS
J.W. GODING: "Monoclonal Antibodies: Principles and Practice", 1993, ACADEMIC PRESS
W. SHI ET AL., IMMUNITY, vol. 13, November 2000 (2000-11-01), pages 633
R. H. FRIEDEL ET AL., J NEUROSCI, vol. 27, 4 April 2007 (2007-04-04), pages 3921
FRIEDEL ET AL., PROC NATL ACAD SCI USA, vol. 102, 13 September 2006 (2006-09-13), pages 13188
K. KOBAYASHI ET AL., J. NEUROSCI, vol. 24, 7 April 2004 (2004-04-07), pages 3480
R. DACQUIN; M. STARBUCK; T. SCHINKE; G. KARSENTY, DEV DYN, vol. 224, June 2002 (2002-06-01), pages 245
K. NISHIKAWA ET AL., J CLIN INVEST, vol. 120, 1 October 2010 (2010-10-01), pages 3455
T. KOGA ET AL., NATURE, vol. 428, 15 April 2004 (2004-04-15), pages 758
B. ZHAO ET AL., NAT MED, vol. 15, September 2009 (2009-09-01), pages 1066
T. KOGA ET AL., NAT MED, vol. 11, August 2005 (2005-08-01), pages 880
H. TAKAYANAGI ET AL., DEV CELL, vol. 3, December 2002 (2002-12-01), pages 889
T. KOGA ET AL., NAT MED, vol. II, August 2005 (2005-08-01), pages 880
BITO, H. ET AL.: "A Critical Role for a Rho-Associated Kinase, p160ROCK, in Determining Axon Outgrowth in Mammalian CNS Neurons", NEURON, vol. 26, 2000, pages 431 - 441, XP002952685, DOI: doi:10.1016/S0896-6273(00)81175-7
I. OINUMA; Y. ISHIKAWA; H. KATOH; M. NEGISHI, SCIENCE, vol. 305, 6 August 2004 (2004-08-06), pages 862
V. PERROT; J. VAZQUEZ-PRADO; J.S. GUTKIND, J BIOL CHEM, vol. 277, 8 November 2002 (2002-11-08), pages 43115
S. MORITA; T. KOJIMA; T. KITAMURA, GENE THER, vol. 7, June 2000 (2000-06-01), pages 1063
M. SHINOHARA ET AL., J. BIO CHEM, vol. 282, 15 June 2007 (2007-06-15), pages 17640
M. SHINOHARA ET AL., J BIO CHEM, vol. 282, 15 June 2007 (2007-06-15), pages 17640
I. ISHIDA ET AL., INT IMMUNOL, vol. 15, August 2003 (2003-08-01), pages 1027
K. SUZUKI; A. KUMANOGOH; H. KIKUTANI, NAT IMMUNOL, vol. 9, January 2008 (2008-01-01), pages 17
J.M. SWIERCZ; T. WORZFELD; S. OFFERMANNS, J BIO CHEM, vol. 283, 25 January 2008 (2008-01-25), pages 1893
J.M. SWIERCZ; R. KUNER; J. BEHRENS; S. OFFENNANNS, NEURON, vol. 35, 3 July 2002 (2002-07-03), pages 51
V. PERROT; J. VAZQUEZ-PRADO; J.S. GUTKIND, J BIO CHEM, vol. 277, 8 November 2002 (2002-11-08), pages 43115
M.H. DRIESSENS; C. OLIVO; K. NAGATA; M. INAGAKI; J.G. COLLARD, FEBS LETT, vol. 529, 9 October 2002 (2002-10-09), pages 168
R. DACQUIN; M. STARBUCK; T. SCHINKE; G. KARSENTY, DEV. DYN, vol. 224, June 2002 (2002-06-01), pages 245
K. MATSUO; N. IRIE, ARCH BIOCHEM BIOPHYS, vol. 473, May 2008 (2008-05-01), pages 201
J.M. SWIERCZ; R. KUNER; J. BEHRENS; S. OFFERMANNS, NEURON, vol. 35, 3 July 2002 (2002-07-03), pages 51
V. PERROT; VAZQUEZ-PRADO; J.S. GUTKIND, J BIO CHEM, vol. 277, 8 November 2002 (2002-11-08), pages 43115
MUTSUMI HIROTANI ET AL.: "Semaphorin 4D to sono Juyotai Plexin B1 no Saibonai Joho Dentatsukei no Kaiseki", BULLETIN OF THE JAPANESE SOCIETY FOR NEUROCHEMISTRY, vol. 40, no. 2/3, 2001, pages 269, XP008172113
TAKESHI SATO ET AL.: "Kotsu Saibo ni Okeru semaphoring Signal no Kento", JOURNAL OF THE JAPANESE STOMATOLOGICAL SOCIETY, vol. 60, no. 1, 10 January 2011 (2011-01-10), pages 112, XP008172118
T NEGISI-KOGA ET AL.: "Suppression of bone formation by osteoclastic expression of semaphorin 4D", NATURE MEDICINE, vol. 17, no. 11, November 2011 (2011-11-01), pages 1473 - 1480, XP055136410
See also references of EP 2711023A4
B.J. DICKSON, SCIENCE, vol. 298, 6 December 2002 (2002-12-06), pages 1959
A.B. HUBER; A.L. KOLODKIN; D.D. GINTY; J.F. CLOUTIER, ANNUAL REVIEW NEUROSCIENCE, vol. 26, 2003, pages 509
N. TAKAGAHARA ET AL., NAT. CELL BIOL, vol. 8, June 2006 (2006-06-01), pages 615
N. IRIE ET AL., CELL METAB, vol. 4, August 2006 (2006-08-01), pages 111
C. ZHAO ET AL., CELL METAB, vol. 4, August 2006 (2006-08-01), pages 111
L OINUMA ET AL., SCIENCE, vol. 305, no. 5685, 6 August 2004 (2004-08-06), pages 862 - 865
ISHIDA MASANARI; KANEDA TOSHIO; MUTO AKIHIO; YOSHIDA MASASHI: "Meeting Program Abstracts of the Japan Society of Bone Metabolism", ANALYSIS OF BIOACTION IN BONE METABOLISM IN OSTEOCLAST-DERIVEDSEMAPHORIN 4D, vol. 25, June 2007 (2007-06-01), pages 266
ROMAIN DACQUIN; CHANTAL DOMENGET; PIERRE JURDIC; IRMA MACHUCA-GAYET: "ASBMR 2010 Annual Meeting Abstracts, Presentation Abstracts, Presentation Number MOO 152", PHYSIOLOGICAL CONTROL OF BONE RESORPTION BY SEMAPHORIN 4D IS DEPENDENT ON OVARIAN FUNCTION
TOMIZUKA ET AL., PROC NATI ACAD SCI USA, vol. 97, pages 722
NAT BIOTECHNOL., vol. 14, 1996, pages 845
KELLER; MILLSTEIN, NATURE, vol. 256, 1975, pages 495 - 497
P.J. DELVES: "Antibody Production Essential Techniques", 1997, WILEY
P. SHEPHERD; C. DEAN: "Monoclonal Antibodies", 2000, OXFORD UNIVERSITY PRESS
J.W. GODING: "Monoclonal Antibodies: Principles and Practice", 1993, ACADEMIC PRESS
W. SHI ET AL., IMMUNITY, vol. 13, November 2000 (2000-11-01), pages 633
R. H. FRIEDEL ET AL., J NEUROSCI, vol. 27, 4 April 2007 (2007-04-04), pages 3921
FRIEDEL ET AL., PROC NATL ACAD SCI USA, vol. 102, 13 September 2006 (2006-09-13), pages 13188
K. KOBAYASHI ET AL., J. NEUROSCI, vol. 24, 7 April 2004 (2004-04-07), pages 3480
R. DACQUIN; M. STARBUCK; T. SCHINKE; G. KARSENTY, DEV DYN, vol. 224, June 2002 (2002-06-01), pages 245
K. NISHIKAWA ET AL., J CLIN INVEST, vol. 120, 1 October 2010 (2010-10-01), pages 3455
T. KOGA ET AL., NATURE, vol. 428, 15 April 2004 (2004-04-15), pages 758
B. ZHAO ET AL., NAT MED, vol. 15, September 2009 (2009-09-01), pages 1066
T. KOGA ET AL., NAT MED, vol. 11, August 2005 (2005-08-01), pages 880
H. TAKAYANAGI ET AL., DEV CELL, vol. 3, December 2002 (2002-12-01), pages 889
T. KOGA ET AL., NAT MED, vol. II, August 2005 (2005-08-01), pages 880
BITO, H. ET AL.: "A Critical Role for a Rho-Associated Kinase, p160ROCK, in Determining Axon Outgrowth in Mammalian CNS Neurons", NEURON, vol. 26, 2000, pages 431 - 441, XP002952685, DOI: doi:10.1016/S0896-6273(00)81175-7
I. OINUMA; Y. ISHIKAWA; H. KATOH; M. NEGISHI, SCIENCE, vol. 305, 6 August 2004 (2004-08-06), pages 862
V. PERROT; J. VAZQUEZ-PRADO; J.S. GUTKIND, J BIOL CHEM, vol. 277, 8 November 2002 (2002-11-08), pages 43115
S. MORITA; T. KOJIMA; T. KITAMURA, GENE THER, vol. 7, June 2000 (2000-06-01), pages 1063
M. SHINOHARA ET AL., J. BIO CHEM, vol. 282, 15 June 2007 (2007-06-15), pages 17640
M. SHINOHARA ET AL., J BIO CHEM, vol. 282, 15 June 2007 (2007-06-15), pages 17640
I. ISHIDA ET AL., INT IMMUNOL, vol. 15, August 2003 (2003-08-01), pages 1027
K. SUZUKI; A. KUMANOGOH; H. KIKUTANI, NAT IMMUNOL, vol. 9, January 2008 (2008-01-01), pages 17
J.M. SWIERCZ; T. WORZFELD; S. OFFERMANNS, J BIO CHEM, vol. 283, 25 January 2008 (2008-01-25), pages 1893
J.M. SWIERCZ; R. KUNER; J. BEHRENS; S. OFFENNANNS, NEURON, vol. 35, 3 July 2002 (2002-07-03), pages 51
V. PERROT; J. VAZQUEZ-PRADO; J.S. GUTKIND, J BIO CHEM, vol. 277, 8 November 2002 (2002-11-08), pages 43115
M.H. DRIESSENS; C. OLIVO; K. NAGATA; M. INAGAKI; J.G. COLLARD, FEBS LETT, vol. 529, 9 October 2002 (2002-10-09), pages 168
R. DACQUIN; M. STARBUCK; T. SCHINKE; G. KARSENTY, DEV. DYN, vol. 224, June 2002 (2002-06-01), pages 245
K. MATSUO; N. IRIE, ARCH BIOCHEM BIOPHYS, vol. 473, May 2008 (2008-05-01), pages 201
J.M. SWIERCZ; R. KUNER; J. BEHRENS; S. OFFERMANNS, NEURON, vol. 35, 3 July 2002 (2002-07-03), pages 51
V. PERROT; VAZQUEZ-PRADO; J.S. GUTKIND, J BIO CHEM, vol. 277, 8 November 2002 (2002-11-08), pages 43115
Attorney, Agent or Firm:
HIROTA, Masanori (JP)
Masaki Hirota (JP)
Masaki Hirota (JP)
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