Title:
OSTEOPOROSIS MODEL COMPRISING CALCIUM PHOSPHATE HYDROGEL COMPOSITION AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/015562
Kind Code:
A1
Abstract:
The present invention relates to a method for preparing a hydrogel composition containing calcium phosphate at a constant content. The hydrogel composition prepared by the method is constant in calcium phosphate content and as such, can be used to quantitate phosphates contained in the hydrogel composition. The present invention relates to an in vitro 3D osteoporosis model comprising the calcium phosphate hydrogel composition. The biogel allows osteoblast cells and osteoclast cells to be co-cultured in a 3D manner therein and as such, can be used for constructing an osteoporosis model according to use and disease phase. In addition, the model comprises a calcium phosphate hydrogel with a constant content of phosphate salt so that the calcium phosphate can be quantitated by measuring the phosphates, whereby selection can be made of therapeutic candidates for osteoporosis and therapeutic effects of the therapeutic agents on osteoporosis can be effectively predicted.
Inventors:
CHA MI SUN (KR)
KIM JUNG JU (KR)
JUNG CHI SUNG (KR)
PARK JIN WOOK (KR)
KIM JUNG JU (KR)
JUNG CHI SUNG (KR)
PARK JIN WOOK (KR)
Application Number:
PCT/KR2020/009694
Publication Date:
January 28, 2021
Filing Date:
July 23, 2020
Export Citation:
Assignee:
MEDIFAB CO LTD (KR)
International Classes:
C08J3/075; A61L27/46; A61L27/52; C08J3/12; C08K3/32; C08L5/08; C08L89/00; C12M1/12; C12N5/077; G01N33/50
Foreign References:
| KR20080096746A | 2008-11-03 | |||
| KR20150087458A | 2015-07-30 | |||
| KR20190035051A | 2019-04-03 | |||
| KR20170078417A | 2017-07-07 | |||
| KR102105549B1 | 2020-04-29 | |||
| KR102095485B1 | 2020-03-31 |
Other References:
TANGPRASERT ATSADAPORN; TANSAKUL CHITTREEYA; THUAKSUBUN NUTTAWUT; MEESANE JIRUT: "Mimicked extracellular matrix of calcified soft tissue based on chitosan/gelatin/compounded calcium phosphate hydrogel to design ex vivo model for heterotopic ossification", MATERIALS & DESIGN, vol. 134, 1 January 2017 (2017-01-01), pages 486 - 493, XP085210366, ISSN: 0264-1275, DOI: 10.1016/j.matdes.2017.08.060
CHAENYUNG CHA; EUN-SEOK KIM; IL WON KIM; HYUNJOON KONG: "Integrative design of a poly(ethylene glycol)-poly(propylene glycol)-alginate hydrogel to control three dimensional biomineralization", BIOMATERIALS, vol. 12, no. 11, 26 December 2010 (2010-12-26), pages 2695 - 2703, XP028145156, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2010.12.038
CHAENYUNG CHA; EUN-SEOK KIM; IL WON KIM; HYUNJOON KONG: "Integrative design of a poly(ethylene glycol)-poly(propylene glycol)-alginate hydrogel to control three dimensional biomineralization", BIOMATERIALS, vol. 12, no. 11, 26 December 2010 (2010-12-26), pages 2695 - 2703, XP028145156, ISSN: 0142-9612, DOI: 10.1016/j.biomaterials.2010.12.038
Attorney, Agent or Firm:
Y.P.LEE, MOCK & PARTNERS (KR)
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