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Patent Searching and Data


Title:
OVARIAN CLEAR CELL CARCINOMA TEST METHOD AND TEST AGENT
Document Type and Number:
WIPO Patent Application WO/2016/084912
Kind Code:
A1
Abstract:
 The problem addressed by the present invention is to provide a method for detecting, with high sensitivity and specificity, ovarian clear cell carcinoma with extremely high malignancy, in benign or malignant ovarian tumors of diverse tissue types, and a reagent which can be used in said method. The present invention provides NT-TFPI2, a new tissue factor pathway inhibitor 2 processing polypeptide as a novel detection marker for ovarian clear cell carcinoma. Ovarian clear cell carcinoma is detected by measuring the amount of NT-TFPI2, or the total amount of NT-TFPI2 and intact TFPI2. The present invention also entails including an antibody which specifically recognizes NT-TFPI2 and intact TFPI2 in the test reagent for ovarian clear cell carcinoma.

Inventors:
ARAKAWA NORIAKI (JP)
HIRANO HISASHI (JP)
MIYAGI ETSUKO (JP)
OHTAKE NORIHISA (JP)
Application Number:
PCT/JP2015/083272
Publication Date:
June 02, 2016
Filing Date:
November 26, 2015
Export Citation:
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Assignee:
PUBLIC UNIV CORP YOKOHAMA CITY (JP)
TOSOH CORP (JP)
International Classes:
C07K14/47; C07K16/38; C12N15/09; G01N27/62; G01N33/574; C12P21/08
Foreign References:
JP2013061321A2013-04-04
JP2013063086A2013-04-11
Other References:
BUTZOW R. ET AL.: "Purification and characterization of placental protein 5", BIOCHEM BIOPHYS RES COMMUN, vol. 150, no. 1, 1988, pages 483 - 490, XP024842561, DOI: doi:10.1016/0006-291X(88)90546-3
NORIAKI ARAKAWA: "Ransogan no Atarashii Kessei Shindan Marker TFPI-2 no Dotei to Rinshoteki Yuyosei", DAI 20 KAI JAPAN SOCIETY FOR PROTEASES IN PATHOPHYSIOLOGY GAKUJUTSU SHUKAI PROGRAM SHOROKUSHU, 2015, pages 35, XP009503224
CHAND H.S. ET AL.: "Structure, function and biology of tissue factor pathway inhibitor-2", THROMBOSIS & HAEMOSTASIS, vol. 94, no. 6, 2005, pages 1122 - 1130, XP055448657
See also references of EP 3225630A4
Attorney, Agent or Firm:
HIRAKAWA, Akira et al. (JP)
Hirakawa 明 (JP)
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