OVER-EXPRESSION OF HADH-DEPENDENT OXIDOREDUCTASE (FUCO) FOR INCREASING FURFURAL OR 5-HYDROXYMETHYLFURFURAL TOLERANCE

Title:

OVER-EXPRESSION OF HADH-DEPENDENT OXIDOREDUCTASE (FUCO) FOR INCREASING FURFURAL OR 5-HYDROXYMETHYLFURFURAL TOLERANCE

Document Type and Number:

WIPO Patent Application WO/2012/135420

Kind Code:

A8

Abstract:

The subject invention pertains to the discovery that the NADH-dependent propanediol oxidoreductase (FucO) can reduce furfural. This allows for a new approach to improve furfural tolerance in bacterial and/or yeast cells used to produce desired products. Thus, novel biocatalysts (bacterial, fungal or yeast cells) exhibiting increased tolerance to furfural and 5-hydroxymethylfurfural (5-HMF) are provided as are methods of making and using such biocatalysts for the production of a desired product.

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Inventors:

MILLER ELLIOT N (US)
ZHANG XUELI (CN)
YOMANO LORRAINE P (US)
WANG XUAN (US)
SHANMUGAM KEELNATHAM T (US)
INGRAM LONNIE O'NEAL (US)

Application Number:

PCT/US2012/031082

Publication Date:

November 08, 2012

Filing Date:

March 29, 2012

Export Citation:

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Assignee:

UNIV FLORIDA (US)
MILLER ELLIOT N (US)
ZHANG XUELI (CN)
YOMANO LORRAINE P (US)
WANG XUAN (US)
SHANMUGAM KEELNATHAM T (US)
INGRAM LONNIE O'NEAL (US)

International Classes:

C12N15/53; C12N15/63; C12P7/10; C12P7/16; C12P7/18; C12P7/40

Attorney, Agent or Firm:

EISENSCHENK, Frank, C. et al. (Lloyd & EisenschenkP.O. Box 14295, Gainesville FL, US)

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