Title:
OXAAZAQUINAZOLINE-7(8H)-KETONE COMPOUND, PREPARATION METHOD THERFOR AND PHARMACEUTICAL APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2020/221239
Kind Code:
A1
Abstract:
Disclosed are an oxazaazaquinazolin-7(8H)-ketone compound with a selective inhibition effect on KRAS gene mutation and pharmaceutically acceptable salts thereof, stereoisomers, solvent compounds or prodrugs (as shown in formula I or formula II, see the details of the definition to each group in the formulas in the specification), as well as the pharmaceutical composition containing the compound, and the application thereof in preparation of cancer medicine.
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Inventors:
ZHOU FUSHENG (CN)
CAI LIJIAN (CN)
JIANG TAO (CN)
ZHAO JICHEN (CN)
LIU YINGTAO (CN)
ZHAO JINZHU (CN)
ZHANG LEITAO (CN)
LIU ZHUBO (CN)
PENG LING (CN)
HE WAN (CN)
YANG HUABIN (CN)
ZHANG TAO (CN)
DING QIAN (CN)
ZHENG BIAO (CN)
LV QIANG (CN)
LAN JIONG (CN)
CAI LIJIAN (CN)
JIANG TAO (CN)
ZHAO JICHEN (CN)
LIU YINGTAO (CN)
ZHAO JINZHU (CN)
ZHANG LEITAO (CN)
LIU ZHUBO (CN)
PENG LING (CN)
HE WAN (CN)
YANG HUABIN (CN)
ZHANG TAO (CN)
DING QIAN (CN)
ZHENG BIAO (CN)
LV QIANG (CN)
LAN JIONG (CN)
Application Number:
PCT/CN2020/087428
Publication Date:
November 05, 2020
Filing Date:
April 28, 2020
Export Citation:
Assignee:
GENFLEET THERAPEUTICS SHANGHAI INC (CN)
ZHEJIANG GENFLEET THERAPEUTICS CO LTD (CN)
ZHEJIANG GENFLEET THERAPEUTICS CO LTD (CN)
International Classes:
C07D498/14; A61K31/519; A61P35/00
Domestic Patent References:
| WO2019215203A1 | 2019-11-14 | |||
| WO2018206539A1 | 2018-11-15 | |||
| WO2017058805A1 | 2017-04-06 |
Other References:
See also references of EP 3964516A4
Attorney, Agent or Firm:
SHANGHAI GOOIP CO., LTD. (CN)
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