Title:
OXACAZONE COMPOUNDS TO TREAT CLOSTRIDIUM DIFFICILE
Document Type and Number:
WIPO Patent Application WO/2016/019588
Kind Code:
A1
Abstract:
Compounds, compositions, and methods for treating C. difficile are provided.
Inventors:
SCHERER CHRISTINA (US)
DUVALL JEREMY (US)
VACCA JOSEPH P (US)
ZHANG MINGLIANG (CN)
HE ZHENMIN (US)
XU HUISHENG (CN)
DUVALL JEREMY (US)
VACCA JOSEPH P (US)
ZHANG MINGLIANG (CN)
HE ZHENMIN (US)
XU HUISHENG (CN)
Application Number:
PCT/CN2014/084037
Publication Date:
February 11, 2016
Filing Date:
August 08, 2014
Export Citation:
Assignee:
BROAD INST INC (US)
WUXI APPTEC TIANJIN CO LTD (CN)
WUXI APPTEC TIANJIN CO LTD (CN)
International Classes:
C07D267/22; A61K31/33; A61P31/04
Domestic Patent References:
| WO2001004103A1 | 2001-01-18 | |||
| WO2012112568A1 | 2012-08-23 |
Foreign References:
| CN102952142A | 2013-03-06 | |||
| JP2005232073A | 2005-09-02 | |||
| JP2006328066A | 2006-12-07 | |||
| CN103804105A | 2014-05-21 | |||
| CN103086996A | 2013-05-08 |
Other References:
ZHU YING HONG ET AL.: "A Facile Route to Unsymmetrical Sulfide", CHINESE CHEMICAL LETTERS, vol. 14, no. 3, 31 December 2003 (2003-12-31), pages 235 - 238
KAMBLE VINOD T. ET AL.: "An efficient method for the synthesis of acylals from aldehydes using silica-supported perchloric acid (HC1O4-SiO2", TETRAHEDRON LETTERS, vol. 31, no. 47, 19 June 2006 (2006-06-19), pages 5573 - 5576
ALIZADEH A. ET AL.: "Highly efficient phosphine-free Suzuki aryl couplings mediated by an in situ generated Pd(OAc)2/metformin complex in green media", TETRAHEDRON LETTERS, vol. 54, no. 4, 14 November 2012 (2012-11-14), pages 291 - 294
NUSSBAUMER PETER ET AL.: "Synthesis and Structure-Activity Relationships of Phenyl- Substituted Benzylamine Antimycotics: A Novel Benzylbenzylamine Antifungal Agent for Systemic Treatment", J. MED. CHEM., vol. 36, no. 15, 31 December 1993 (1993-12-31), pages 2115 - 2120
ADAMSKI-WERNER SARA L. ET AL.: "Diflunisal Analogues Stabilize the Native State of Transthyretin. Potent Inhibition of Amyloidogenesis", J. MED. CHEM., vol. 2, no. 47, 11 December 2003 (2003-12-11), pages 355 - 374
ZHANG TONY Y. ET AL.: "An Easily Prepared, Air and Moisture Stable, Resin-bound Palladium Catalyst for Suzuki Cross-Coupling Reactions", TETRAHEDRON LETTERS, vol. 40, no. 32, 31 December 1999 (1999-12-31), pages 5813 - 5816
KAMBLE VINOD T. ET AL.: "An efficient method for the synthesis of acylals from aldehydes using silica-supported perchloric acid (HC1O4-SiO2", TETRAHEDRON LETTERS, vol. 31, no. 47, 19 June 2006 (2006-06-19), pages 5573 - 5576
ALIZADEH A. ET AL.: "Highly efficient phosphine-free Suzuki aryl couplings mediated by an in situ generated Pd(OAc)2/metformin complex in green media", TETRAHEDRON LETTERS, vol. 54, no. 4, 14 November 2012 (2012-11-14), pages 291 - 294
NUSSBAUMER PETER ET AL.: "Synthesis and Structure-Activity Relationships of Phenyl- Substituted Benzylamine Antimycotics: A Novel Benzylbenzylamine Antifungal Agent for Systemic Treatment", J. MED. CHEM., vol. 36, no. 15, 31 December 1993 (1993-12-31), pages 2115 - 2120
ADAMSKI-WERNER SARA L. ET AL.: "Diflunisal Analogues Stabilize the Native State of Transthyretin. Potent Inhibition of Amyloidogenesis", J. MED. CHEM., vol. 2, no. 47, 11 December 2003 (2003-12-11), pages 355 - 374
ZHANG TONY Y. ET AL.: "An Easily Prepared, Air and Moisture Stable, Resin-bound Palladium Catalyst for Suzuki Cross-Coupling Reactions", TETRAHEDRON LETTERS, vol. 40, no. 32, 31 December 1999 (1999-12-31), pages 5813 - 5816
Attorney, Agent or Firm:
PANAWELL & PARTNERS, LLC (China Life Tower16 Chao Yang Men Wai Street, Chaoyang District, Beijing 0, CN)
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