Title:
OXADIAZOLE LINKERS AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2019/011078
Kind Code:
A1
Abstract:
Provided is oxadiazole linkers and use thereof, more specifically to the compounds represented by formulas (I), (II), and (III), and their use in the preparation of antibody-drug conjugates (ADCs). The ADCs obtained from said oxadiazole linkers have high homogeneity and stability, and could be used effectively for the treatment of various diseases including tumors. The definition of the groups in formula (I), (II), and (III) is the same as that in the description.
Inventors:
HAN NIANHE (US)
AN DEQIANG (CN)
ZENG DI (CN)
WANG BAOXIANG (CN)
LI HUALI (CN)
CHEN HANG (CN)
YANG CHUN (CN)
AN DEQIANG (CN)
ZENG DI (CN)
WANG BAOXIANG (CN)
LI HUALI (CN)
CHEN HANG (CN)
YANG CHUN (CN)
Application Number:
PCT/CN2018/089767
Publication Date:
January 17, 2019
Filing Date:
June 04, 2018
Export Citation:
Assignee:
NEWBIO THERAPEUTICS INC (CN)
International Classes:
C07D271/10; A61K31/10; A61K31/4245; A61P29/00; A61P35/00; A61P37/00; C07D271/113
Domestic Patent References:
| WO2014144878A2 | 2014-09-18 | |||
| WO2016059622A2 | 2016-04-21 |
Foreign References:
| CN103864711A | 2014-06-18 |
Attorney, Agent or Firm:
GE CHENG & CO.LTD. (CN)
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