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Title:
OXAZOLIDINONE DERIVATIVE HAVING 7-MEMBERED HETERO RING
Document Type and Number:
WIPO Patent Application WO/2009/044777
Kind Code:
A1
Abstract:
Disclosed are a novel oxazolidinone derivative represented by the formula (I), a pharmaceutically acceptable salt thereof, and a solvate of the derivative or the pharmaceutically acceptable salt, which are useful as antibacterial agents. (I) wherein the ring A represents (A-1) a 7-membered monocyclic hetero ring having three N atoms, (A-2) a 7-membered monocyclic hetero ring having two N atoms and one O atom, or (A-3) a 7-membered monocyclic hetero ring having two N atoms and one S atom, SO or SO2, in which the monocyclic hetero ring may be substituted, may have an unsaturated bond, and may be fused with another ring; X1 represents a single bond, a hetero atom-containing group selected from the group consisting of -O-, -S-, -NR2-, -CO-, -CS-, -CONR3-, -NR4CO-, -SO2NR5- and -NR6SO2- [wherein R2 to R6 independently represent a hydrogen or a lower alkyl group], or a lower alkylene or alkenylene which may have the hetero atom-containing group therein; the ring B represents a carbon ring which may be substituted or a hetero ring which may be substituted; and R1 represents a hydrogen or an organic residue which can bind to position-5 in an oxazolidinone ring in an oxazolidinone antibacterial agent.

Inventors:
SUZUKI HIDEYUKI (JP)
UTSUNOMIYA IWAO (JP)
SHUDO KOICHI (JP)
IWAKI TSUTOMU (JP)
YASUKATA TATSURO (JP)
Application Number:
PCT/JP2008/067843
Publication Date:
April 09, 2009
Filing Date:
October 01, 2008
Export Citation:
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Assignee:
RES FOUND ITSUU LAB (JP)
SHIONOGI & CO (JP)
SUZUKI HIDEYUKI (JP)
UTSUNOMIYA IWAO (JP)
SHUDO KOICHI (JP)
IWAKI TSUTOMU (JP)
YASUKATA TATSURO (JP)
International Classes:
C07D413/10; A61K31/55; A61K31/553; A61P31/04; C07D413/14; C07D471/14; C07D487/04
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Other References:
DAS, B. ET AL.: "Synthesis and SAR of novel oxazolidinones: discovery of ranbezolid", BIOORG. MED. CHEM. LETT., vol. 15, no. 19, 2005, pages 4261 - 4267, XP027388780
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See also references of EP 2208729A4
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BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 15, 2005, pages 2834 - 2839
Attorney, Agent or Firm:
TANAKA, Mitsuo et al. (IMP Building3-7, Shiromi 1-chome,Chuo-ku, Osaka-shi, Osaka 01, JP)
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