Title:
OXIDATIVE METHOD FOR ATTACHMENT OF GLYCOPROTEINS OR GLYCOPEPTIDES TO SURFACES OF MEDICAL DEVICES
Document Type and Number:
WIPO Patent Application WO1999027968
Kind Code:
A3
Abstract:
A method for making a medical device having at least one glycoprotein and/or glycopeptide immobilized on a substrate surface is provided. The method may include oxidizing 1,2 dihydroxy moieties with a periodate to form an aldehyde-functional material; combining the aldehyde-functional material with an amino-functional material to bond the two materials together through an imine moiety; and reacting the imine moiety with a reducing agent to form a secondary amine. Another method of the present invention may be employed to crosslink glycoproteins and/or glycopeptides immobilized on medical device surfaces. Additionally, one method of the present invention may be employed to crosslink glycoproteins and/or glycopeptides, thereby forming a crosslinked biomaterial or a crosslinked medical device coating.
Inventors:
KEOGH JAMES R
Application Number:
PCT/US1998/025656
Publication Date:
September 02, 1999
Filing Date:
December 03, 1998
Export Citation:
Assignee:
MEDTRONIC INC (US)
International Classes:
A61L27/28; A61L27/34; A61L29/08; A61L31/08; A61L31/10; A61L33/00; C07K14/00; C08J7/00; (IPC1-7): A61L27/00; A61L33/00
Foreign References:
| EP0826382A2 | 1998-03-04 | |||
| US4642242A | 1987-02-10 | |||
| US5679659A | 1997-10-21 | |||
| US5258501A | 1993-11-02 | |||
| US5324647A | 1994-06-28 |
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