Title:
OXO-PYRIDOIMIDAZOLE-CARBOXAMIDES: GABA BRAIN RECEPTOR LIGANDS
Document Type and Number:
WIPO Patent Application WO2000010973
Kind Code:
A3
Abstract:
Disclosed are compounds of formula (I), or the pharmaceutically acceptable non-toxic salts thereof where R1-R4 and A are defined herein, which compounds are highly selective agonists, antagonists or inverse agonists for GABAa brain receptors or prodrugs of agonists, antagonists or inverse agonists for GABAa brain receptors and are, therefore, useful in the diagnosis and treatment of anxiety, Down Syndrome, depression, sleep, cognitive and seizure disorders, overdose with benzodiazepine drugs and for enhancement of altertness.
Inventors:
RACHWAL BOGUMILA (US)
ALBAUGH PAMELA (US)
SHAW KENNETH (US)
ALBAUGH PAMELA (US)
SHAW KENNETH (US)
Application Number:
PCT/US1999/019400
Publication Date:
June 29, 2000
Filing Date:
August 25, 1999
Export Citation:
Assignee:
NEUROGEN CORP (US)
RACHWAL BOGUMILA (US)
ALBAUGH PAMELA (US)
SHAW KENNETH (US)
RACHWAL BOGUMILA (US)
ALBAUGH PAMELA (US)
SHAW KENNETH (US)
International Classes:
A61K31/437; A61P25/22; A61P25/24; A61P25/30; A61P43/00; C07D471/04; (IPC1-7): C07D471/04
Domestic Patent References:
| WO1998015553A1 | 1998-04-16 | |||
| WO1994004532A1 | 1994-03-03 |
Other References:
MARYANOFF B E ET AL: "Potential anxiolytic agents. 3. Novel A-ring modified pyrido[1,2-a]benzimidazoles", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,GB,OXFORD, vol. 9, no. 11, 7 June 1999 (1999-06-07), pages 1547 - 1552, XP004169636, ISSN: 0960-894X
CHEMICAL ABSTRACTS, vol. 131, no. 13, 1999, Columbus, Ohio, US; abstract no. 171833b, J.H. COHEN ET AL.: "Pocess research for the synthesis of RWJ-51204, a novel anxiolytic agent" page 806; XP002136278
CHEMICAL ABSTRACTS, vol. 131, no. 13, 1999, Columbus, Ohio, US; abstract no. 171833b, J.H. COHEN ET AL.: "Pocess research for the synthesis of RWJ-51204, a novel anxiolytic agent" page 806; XP002136278
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