Title:
α-OXOACYL AMINO-CAPROLACTAM DERIVATIVE
Document Type and Number:
WIPO Patent Application WO/2014/199644
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a pharmaceutical composition that is useful for the treatment of diseases that are caused by an increase in bone resorption and that does not cause serious side effects even when used in combination with another drug. The present invention relates to: an α-oxoacyl amino-caprolactam derivative that is represented by formula (I) (in the formula, X is -O- or -N(R1)- and R1 represents an alkoxycarbonyl group having 1-10 carbon atoms); and a bone resorption inhibitor containing the α-oxoacyl amino-caprolactam derivative.
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Inventors:
KOBAYASHI NOBUO (JP)
KOJI TSUNEO (JP)
KUNII HISATOMO (JP)
ISHIKAWA MIZUHO (JP)
MORITA DAISUKE (JP)
KOJI TSUNEO (JP)
KUNII HISATOMO (JP)
ISHIKAWA MIZUHO (JP)
MORITA DAISUKE (JP)
Application Number:
PCT/JP2014/003158
Publication Date:
December 18, 2014
Filing Date:
June 13, 2014
Export Citation:
Assignee:
SEIKAGAKU KOGYO CO LTD (JP)
International Classes:
C07K5/065; A61K38/00; A61P3/04; A61P7/00; A61P19/02; A61P19/08; A61P19/10; A61P29/00; A61P35/00; A61P35/04
Domestic Patent References:
| WO1998001133A1 | 1998-01-15 | |||
| WO2001058886A1 | 2001-08-16 | |||
| WO2003075836A2 | 2003-09-18 |
Foreign References:
| JP2000204071A | 2000-07-25 | |||
| JPS49831B1 | 1974-01-10 | |||
| JP2007236327A | 2007-09-20 | |||
| JP2000204071A | 2000-07-25 | |||
| JP2007236327A | 2007-09-20 |
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J. BIOL. CHEM., vol. 271, 1996, pages 12511
SCIENCE, vol. 273, 1996, pages 1236
J. BIOL. CHEM., vol. 271, 1996, pages 2126
BIOL. PHARM. BULL., vol. 19, 1996, pages 1026
NATURE STRUCTURAL BIOLOGY, vol. 4, 1997, pages 105
J. MED. CHEM., vol. 38, 1995, pages 3193
ENZYME INHIBITION, vol. 3, 1989, pages 13
BIOCHEM. BIOPHYS. RES. COMMUN., vol. 153, 1988, pages 1201
J. BIOCHEM., vol. 88, 1980, pages 1805
NATURE STRUCTURAL BIOLOGY, vol. 4, 1997, pages 109
PROC. NATL. ACAD. SCI. USA., vol. 94, 1997, pages 14249
J. AM. CHEM. SOC., vol. 120, 1998, pages 9114
J. MED. CHEM., vol. 41, 1998, pages 3563
BIOORG. MED. CHEM. LETT., vol. 14, 2004, pages 4897
"Rinsho Yakubutsu Dotaigaku", 2009, NANKODO CO., LTD., pages: 71 - 85,173-2
NICHIYAKURISHI (FOLIA PHARMACOL. JPN., vol. 134, 2009, pages 285 - 288
PHYTOMEDICINE, vol. 18, no. 6, 15 April 2011 (2011-04-15), pages 533 - 8
ANNU. REV. PHARMACOL. TOXICOL., vol. 40, 2000, pages 133 - 57
TEZUKA ET AL., J. BIOL. CHEM., vol. 269, 1994, pages 1106 - 1109
AIBE ET AL., BIOL. PHARM. BULL., vol. 19, 1996, pages 1026 - 1031
BIOCHEM BIOPHYS RES COMMUN., vol. 125, 1984, pages 441 - 447
FEBS LETT., vol. 321, no. 2-3, 1993, pages 247 - 250
NEWTON ET AL., DRUG METAB. DISPOS, vol. 23, 1995, pages 154 - 158
Attorney, Agent or Firm:
SAEKI, Norio et al. (JP)
Norio Saeki (JP)
Norio Saeki (JP)
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