OXYLIPINS FROM LONG CHAIN POLYUNSATURATED FATTY ACIDS AND METHODS OF MAKING AND USING THE SAME

Title:

OXYLIPINS FROM LONG CHAIN POLYUNSATURATED FATTY ACIDS AND METHODS OF MAKING AND USING THE SAME

Document Type and Number:

WIPO Patent Application WO2006055965

Kind Code:

A3

Abstract:

Disclosed are novel oxylipins, referred to herein as docosanoids, that are derived from C22 polyunsaturated fatty acids, and method of making and using such oxylipins. Also disclosed is the use of docosapentaenoic acid (C22:5n-6) (DPAn-6), docosapentaenoic acid (C22:5n-3) (DPAn-3), and docosatetraenoic acid (DTAn-6: C22:4n-6) as substrates for the production of novel oxylipins, and to the oxylipins produced thereby. Also disclosed is the use of DPAn-6, DPAn-3, DTAn-6, and/or the oxylipins derived therefrom, and/or novel docosanoids derived from the structures of C22 fatty acids, in therapeutic and nutritional or cosmetic applications, and particularly as anti-inflammatory or anti-neurodegenerative compounds. The invention also relates to novel ways of producing long chain polyunsaturated acid (LCPUFA)-rich oils and compositions that contain enhanced and effective amounts of LCPUFA-derived oxylipins, and particularly, docosanoids.

Inventors:

ARTERBURN LINDA MARY (US)
BARCLAY WILLIAM (US)
DANGI BINDI (US)
FLATT JAMES (US)
LEE JUNG (US)
VAN ELSWYK MARY (US)

Application Number:

PCT/US2005/042462

Publication Date:

November 30, 2006

Filing Date:

November 21, 2005

Export Citation:

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Assignee:

MARTEK BIOSCIENCES CORP (US)
ARTERBURN LINDA MARY (US)
BARCLAY WILLIAM (US)
DANGI BINDI (US)
FLATT JAMES (US)
LEE JUNG (US)
VAN ELSWYK MARY (US)

International Classes:

C07C53/00; A61K31/02; C07C57/00; C12P7/64

Foreign References:

US6174695B1

2001-01-16

Other References: