P-TOLUENESULFONIC ACID SALT OF LENVATINIB, CRYSTALLINE FORM AND PREPARATION METHOD THEREOF

Title:

P-TOLUENESULFONIC ACID SALT OF LENVATINIB, CRYSTALLINE FORM AND PREPARATION METHOD THEREOF

Document Type and Number:

WIPO Patent Application WO/2016/155560

Kind Code:

A1

Abstract:

Disclosed are p-toluenesulfonic acid salt of lenvatinib, crystalline form and preparation method thereof. Particularly, disclosed are p-toluenesulfonic acid salt of lenvatinib, crystalline form I and preparation method thereof. The preparation method comprises: crystallizing solid of any crystalline or amorphous p-toluenesulfonic acid salt of lenvatinib in a sole organic solvent or a mixed organic solvent thereof to obtain crystalline form I of the p-toluenesulfonic acid of lenvatinib. The obtained crystalline form I of the p-toluenesulfonic acid salt of lenvatinib in the present invention has good polymorphic stability and chemical stability, and the solvent used for crystallization has low toxicity and low residue.

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Inventors:

GAO JUNLONG (CN)
LIU KAI (CN)
GE WENLEI (CN)

Application Number:

PCT/CN2016/077230

Publication Date:

October 06, 2016

Filing Date:

March 24, 2016

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Assignee:

JIANGSU HENGRUI MEDICINE CO (CN)

International Classes:

C07D215/48; A61K31/47; A61P35/00

Foreign References:

CN1890220A	2007-01-03
CN101001629A	2007-07-18
CN101233111A	2008-07-30

Attorney, Agent or Firm:

GE CHENG & CO., LTD. (CN)
北京戈程知识产权代理有限公司 (CN)

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