P2X4 RECEPTOR ANTAGONIST

WIPO Patent Application WO/2007/072974

A1

A compound represented by the general formula (I) below or a salt thereof is used as a P2X4 receptor antagonist. (I) (In the formula, X represents S or CH2; Y represents O, S or NH; R1 represents a hydrogen atom, an alkyl group having 1-8 carbon atoms or the like; R2 and R3 respectively represent a hydrogen atom, an alkyl group having 1-8 carbon atoms, an alkoxy group having 1-8 carbon atoms, a halogen atom, a hydroxyl group or the like; R4 and R5 respectively represent a hydrogen atom, an alkyl group having 1-8 carbon atoms or the like; and a double line composed of a broken line and a solid line represents a single bond or a double bond.)

JPH03197462	BENZOFUSED-N-CONTAINING HETEROCYCLE DERIVATIVE
WO/2006/006180	A PROCESS FOR PRODUCING PURE FORM OF 2-METHYL-4-(4-METHYL-1-PIPERAZINYL)-10H-THIENO[2,3-b][1,5]BENZODIAZEPINE
WO/2001/053255	GAMMA-SECRETASE INHIBITORS

SAKUMA SHOGO (JP)
ENDO TSUYOSHI (JP)
IMAI TOSHIYASU (JP)
KANAKUBO NORIKO (JP)
YAMAKAWA TOMIO (JP)
TSUDA MAKOTO (JP)
INOUE KAZUHIDE (JP)
HIRATE KENJI

PCT/JP2006/325696

June 28, 2007

December 19, 2006

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NIPPON CHEMIPHAR CO (JP)
HIRATE TAKAKO (JP)
SAKUMA SHOGO (JP)
ENDO TSUYOSHI (JP)
IMAI TOSHIYASU (JP)
KANAKUBO NORIKO (JP)
YAMAKAWA TOMIO (JP)
TSUDA MAKOTO (JP)
INOUE KAZUHIDE (JP)

C07D243/10; A61K31/551; A61P25/04; C07D495/04

WO2004085440A1

2004-10-07

US20050074819A1

2005-04-07

WERMUTH C.G.: "Saishin Soyaku kagaku first", 1998, TECHNOMICS INC., pages: 241 - 243, XP003014709

CHIGUSA, Shinichi (2-3, Iwamoto-cho 2-chom, Chiyoda-ku Tokyo 32, JP)

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