Title:
P2X4 RECEPTOR ANTAGONIST
Document Type and Number:
WIPO Patent Application WO/2012/017876
Kind Code:
A1
Abstract:
The present invention uses a compound represented by general formula (II) or a pharmacologically acceptable salt thereof as a P2X4 receptor antagonist. (In the formula, R11 and R12 each represents a hydrogen atom, an alkyl group having 1-8 carbon atoms, or the like; R13 represents a hydrogen atom, an alkyl group having 1-8 carbon atoms, or the like; R14 represents an alkoxy group having 1-8 carbon atoms, a hydroxyl group, a cyano group, an optionally substituted heterocyclic group or the like; and AA represents a naphthalene ring or the like.)
Inventors:
USHIODA MASATOSHI (JP)
SAKUMA SHOGO (JP)
IMAI TOSHIYASU (JP)
INOUE KAZUHIDE (JP)
SAKUMA SHOGO (JP)
IMAI TOSHIYASU (JP)
INOUE KAZUHIDE (JP)
Application Number:
PCT/JP2011/067028
Publication Date:
February 09, 2012
Filing Date:
July 27, 2011
Export Citation:
Assignee:
NIPPON CHEMIPHAR CO (JP)
USHIODA MASATOSHI (JP)
SAKUMA SHOGO (JP)
IMAI TOSHIYASU (JP)
INOUE KAZUHIDE (JP)
USHIODA MASATOSHI (JP)
SAKUMA SHOGO (JP)
IMAI TOSHIYASU (JP)
INOUE KAZUHIDE (JP)
International Classes:
C07D239/70; A61K31/517; A61P25/04; A61P43/00; C07D403/10
Domestic Patent References:
| WO2008023847A1 | 2008-02-28 | |||
| WO2007074940A1 | 2007-07-05 | |||
| WO2004085440A1 | 2004-10-07 | |||
| WO2008023847A1 | 2008-02-28 |
Foreign References:
| US3963717A | 1976-06-15 | |||
| JP2008526996A | 2008-07-24 | |||
| US20050074819A1 | 2005-04-07 | |||
| US3963717A | 1976-06-15 |
Other References:
ROBEV S: "Quinazolone synthesis from N-aryl-N'-arylaminoformylated amidines", DOKLADY BOLGARSKOI AKADEMII NAUK, vol. 40, no. 12, 1987, pages 41 - 44, XP009174605
See also references of EP 2617717A4
BUELL ET AL., EMBO J., vol. 15, 1996, pages 55 - 62
SEGUELA ET AL., J. NEUROSCI., vol. 16, 1996, pages 448 - 455
BO ET AL., FEBS LETT., vol. 375, 1995, pages 129 - 133
SOTO ET AL., PROC. NATL. ACAD. SCI. USA, vol. 93, 1996, pages 3684 - 3788
WANG ET AL., BIOCHEM. RES. COMMUN., vol. 220, 1996, pages 196 - 202
TSUDA ET AL., NATURE, vol. 424, 2003, pages 778 - 783
JEFFREY A.M. COULL ET AL., NATURE, vol. 438, 2005, pages 1017 - 1021
"Paper Abstract of Lecture Program P3-N-114", THE 49TH ANNUAL MEETING OF JAPANESE SOCIETY FOR NEUROCHEMISTRY, 2006
DOKLADY BOLGARSKOI AKADEMII NAUK, vol. 40, no. 12, 1987, pages 41 - 4
See also references of EP 2617717A4
BUELL ET AL., EMBO J., vol. 15, 1996, pages 55 - 62
SEGUELA ET AL., J. NEUROSCI., vol. 16, 1996, pages 448 - 455
BO ET AL., FEBS LETT., vol. 375, 1995, pages 129 - 133
SOTO ET AL., PROC. NATL. ACAD. SCI. USA, vol. 93, 1996, pages 3684 - 3788
WANG ET AL., BIOCHEM. RES. COMMUN., vol. 220, 1996, pages 196 - 202
TSUDA ET AL., NATURE, vol. 424, 2003, pages 778 - 783
JEFFREY A.M. COULL ET AL., NATURE, vol. 438, 2005, pages 1017 - 1021
"Paper Abstract of Lecture Program P3-N-114", THE 49TH ANNUAL MEETING OF JAPANESE SOCIETY FOR NEUROCHEMISTRY, 2006
DOKLADY BOLGARSKOI AKADEMII NAUK, vol. 40, no. 12, 1987, pages 41 - 4
Attorney, Agent or Firm:
Chigusa, Shinichi (JP)
1000 Shin-ichi Kusa (JP)
1000 Shin-ichi Kusa (JP)
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